Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy.
cancer therapy
chemotherapeutics
drug delivery systems
molecularly imprinted polymers
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
13 Dec 2019
13 Dec 2019
Historique:
received:
14
11
2019
revised:
03
12
2019
accepted:
11
12
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
19
12
2019
Statut:
epublish
Résumé
Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics' release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.
Identifiants
pubmed: 31847103
pii: polym11122085
doi: 10.3390/polym11122085
pmc: PMC6960886
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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