The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 12 2019
17 12 2019
Historique:
received:
07
08
2019
accepted:
02
12
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
6
11
2020
Statut:
epublish
Résumé
Laminin-γ1 is required for early embryonic development; however, the need for laminin-γ1 synthesis in adulthood is unknown. A global and inducible mouse model of laminin-γ1 deficiency was generated to address this question. Genetic ablation of the Lamc1 gene in adult mice was rapidly lethal. Despite global Lamc1 gene deletion in tamoxifen-induced mutant mice, there was minimal change in total cardiac, pulmonary, hepatic or renal laminin protein. In contrast, laminin-γ1 was significantly depleted in the small intestines, which showed crypt hyperplasia and dissociation of villous epithelium from adjacent mesenchyme. We conclude that the physiologic requirement for laminin-γ1 synthesis in adult mice is dependent on a tissue-specific basal rate of laminin-γ1 turnover that results in rapid depletion of laminin-γ1 in the intestine.
Identifiants
pubmed: 31848396
doi: 10.1038/s41598-019-55844-x
pii: 10.1038/s41598-019-55844-x
pmc: PMC6917708
doi:
Substances chimiques
Laminin
0
laminin gamma 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19303Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL127187
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111822
Pays : United States
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