Personalized pediatric anesthesia and pain management: problem-based review.

Anesthesia / methods Anesthesiology / trends Apnea / chemically induced Child Child, Preschool Humans Malignant Hyperthermia / etiology Pain / drug therapy Pain Management / methods Pediatrics Precision Medicine Succinylcholine / adverse effects
anesthesia opioids pain medicine pediatric anesthesia personalized medicine pharmacogenetics

Journal

Pharmacogenomics
ISSN: 1744-8042
Titre abrégé: Pharmacogenomics
Pays: England
ID NLM: 100897350

Informations de publication

Date de publication:
01 2020
Historique:
entrez: 19 12 2019
pubmed: 19 12 2019
medline: 22 9 2020
Statut: ppublish

Résumé

Pharmacogenetics, the genetic influence on the interpersonal variability in drug response, has enabled tailored pharmacotherapy and emerging 'personalized medicine.' Although oncology spearheaded the clinical implementation of personalized medicine, other specialties are rapidly catching up. In anesthesia, classical examples of genetically mediated idiosyncratic reactions have been long known (e.g., malignant hyperthermia and prolonged apnea after succinylcholine). The last two decades have witnessed an expanding body of pharmacogenetic evidence in anesthesia. This review highlights some of the prominent pharmacogenetic associations studied in anesthesia and pain management, with special focus on pediatric anesthesia.

Identifiants

DOI: 10.2217/pgs-2019-0108 PMID: 31849281 PMC: PMC7132778
pubmed: 31849281
doi: 10.2217/pgs-2019-0108
pmc: PMC7132778
doi:

Substances chimiques

Succinylcholine J2R869A8YF

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

55-73

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD089458
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD094311
Pays : United States

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Auteurs

Senthil Packiasabapathy (S)

Department of Anesthesia, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.

Valluvan Rangasamy (V)

Department of Anesthesia, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.

Nicole Horn (N)

Department of Anesthesia, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.

Michele Hendrickson (M)

Department of Anesthesia, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.

Janelle Renschler (J)

Department of Anesthesia, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.

Senthilkumar Sadhasivam (S)

Department of Anesthesia, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.

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Classifications MeSH

questionsmedicales.fr › Anesthésie et analgésie › Anesthésie › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Professions de santé › Médecine › Anesthésiologie › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Apnée › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Troubles de la température corporelle › Hyperthermie maligne › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Gestion de la douleur › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Professions de santé › Médecine › Pédiatrie › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Personalized pediatric anesthesia and pain...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Choline › Suxaméthonium › Personalized pediatric anesthesia and pain...