Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation.
AAV
cell-type specificity
gene delivery
intersectional methods
neuroscience
targeted neuronal manipulation
viral vectors
virus technologies
Journal
Frontiers in neuroanatomy
ISSN: 1662-5129
Titre abrégé: Front Neuroanat
Pays: Switzerland
ID NLM: 101477943
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
08
2019
accepted:
30
10
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
19
12
2019
Statut:
epublish
Résumé
Cell-type-specific expression of molecular tools and sensors is critical to construct circuit diagrams and to investigate the activity and function of neurons within the nervous system. Strategies for targeted manipulation include combinations of classical genetic tools such as Cre/loxP and Flp/FRT, use of cis-regulatory elements, targeted knock-in transgenic mice, and gene delivery by AAV and other viral vectors. The combination of these complex technologies with the goal of precise neuronal targeting is a challenge in the lab. This report will discuss the theoretical and practical aspects of combining current technologies and establish best practices for achieving targeted manipulation of specific cell types. Novel applications and tools, as well as areas for development, will be envisioned and discussed.
Identifiants
pubmed: 31849618
doi: 10.3389/fnana.2019.00093
pmc: PMC6902037
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
93Informations de copyright
Copyright © 2019 Haery, Deverman, Matho, Cetin, Woodard, Cepko, Guerin, Rego, Ersing, Bachle, Kamens and Fan.
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