Exosomes From Astrocyte Processes: Signaling to Neurons.
adult astrocytes
astrocyte processes
cerebral cortex
ex-vivo
exosomes
extracellular vesicles
neuroglobin
neuron-astrocyte cocultures
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
07
2019
accepted:
13
11
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
19
12
2019
Statut:
epublish
Résumé
It is widely recognized that extracellular vesicles subserve non-classical signal transmission in the central nervous system. Here we assess if the astrocyte processes, that are recognized to play crucial roles in intercellular communication at the synapses and in neuron-astrocyte networks, could convey messages through extracellular vesicles. Our findings indicate, for the first time that freshly isolated astrocyte processes prepared from adult rat cerebral cortex, can indeed participate to signal transmission in central nervous system by releasing exosomes that by volume transmission might target near or long-distance sites. It is noteworthy that the exosomes released from the astrocyte processes proved ability to selectively target neurons. The astrocyte-derived exosomes were proven positive for neuroglobin, a protein functioning as neuroprotectant against cell insult; the possibility that exosomes might transfer neuroglobin to neurons would add a mechanism to the potential astrocytic neuroprotectant activity. Notably, the exosomes released from the processes of astrocytes maintained markers, which prove their parental astrocytic origin. This potentially allows the assessment of the cellular origin of exosomes that might be recovered from body fluids.
Identifiants
pubmed: 31849688
doi: 10.3389/fphar.2019.01452
pmc: PMC6901013
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1452Informations de copyright
Copyright © 2019 Venturini, Passalacqua, Pelassa, Pastorino, Tedesco, Cortese, Gagliani, Leo, Maura, Guidolin, Agnati, Marcoli and Cervetto.
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