Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus
ATG7
autophagy
encephalomyocarditis virus
replication
transmembrane protein 39A
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
08
2019
accepted:
05
11
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
19
12
2019
Statut:
epublish
Résumé
Encephalomyocarditis virus (EMCV) causes encephalitis, myocarditis, neuropathy, reproductive disorders, and diabetes in animals. EMCV is known to induce cell autophagy; however, the molecular mechanisms underlying this remain unclear. Here, we show that the type III-transmembrane protein, transmembrane protein 39A (TMEM39A), plays a critical role in EMCV replication. We showed that EMCV GS01 strain infection upregulated TMEM39A expression. Importantly, EMCV induced autophagy in a range of host cells. The autophagy chemical inhibitor, 3-MA, inhibited EMCV replication and reduced TMEM39A expression. This is the first study demonstrating TMEM39A promoting the replication of EMCV
Identifiants
pubmed: 31849860
doi: 10.3389/fmicb.2019.02680
pmc: PMC6901969
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2680Informations de copyright
Copyright © 2019 Li, Ma, Li, Li, Zhang, Xie, Bai, Idris and Feng.
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