Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection.
Adult
Biomarkers
CD4 Lymphocyte Count
CD4-CD8 Ratio
Central Nervous System Diseases
/ diagnosis
Cognitive Dysfunction
/ diagnosis
Cohort Studies
Female
HIV Infections
/ complications
Humans
Interferon Regulatory Factors
/ genetics
Magnetic Resonance Imaging
Male
Middle Aged
Monocytes
/ immunology
Myeloid Cells
/ immunology
Viral Load
HIV-1
IRF-8
anti-retroviral therapy
central nervous system
cognition
dendritic cells
interferon
monocytes
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
08
2019
accepted:
14
11
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
4
11
2020
Statut:
epublish
Résumé
Cognitive dysfunction persists in 30-50% of chronically HIV-infected individuals despite combination antiretroviral therapy (ART). Although monocytes are implicated in poor cognitive performance, distinct biological mechanisms associated with cognitive dysfunction in HIV infection are unclear. We previously showed that a regulatory region of the
Identifiants
pubmed: 31849969
doi: 10.3389/fimmu.2019.02789
pmc: PMC6895026
doi:
Substances chimiques
Biomarkers
0
Interferon Regulatory Factors
0
interferon regulatory factor-8
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2789Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL140271
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103466
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007601
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113134
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007584
Pays : United States
Informations de copyright
Copyright © 2019 D'Antoni, Kallianpur, Premeaux, Corley, Fujita, Laws, Ogata-Arakaki, Chow, Khadka, Shikuma and Ndhlovu.
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