Innate Immune Responses in the Outcome of Haploidentical Hematopoietic Stem Cell Transplantation to Cure Hematologic Malignancies.
Combined Modality Therapy
Cytokines
/ genetics
Genetic Engineering
Graft vs Host Disease
/ diagnosis
Hematologic Neoplasms
/ genetics
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Immune Reconstitution
Immunity, Innate
Killer Cells, Natural
/ immunology
Molecular Targeted Therapy
/ methods
Prognosis
T-Lymphocyte Subsets
/ immunology
Transplantation, Haploidentical
Treatment Outcome
alloreactivity
haploidentical hematopoietic stem cell transplantation
immune-reconstitution
innate lymphocytes
innate lymphoid cells
natural killer cells
γδ T cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
07
2019
accepted:
14
11
2019
entrez:
19
12
2019
pubmed:
19
12
2019
medline:
11
11
2020
Statut:
epublish
Résumé
In the context of allogeneic transplant platforms, human leukocyte antigen (HLA)-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) represents one of the latest and most promising curative strategies for patients affected by high-risk hematologic malignancies. Indeed, this platform ensures a suitable stem cell source immediately available for virtually any patents in need. Moreover, the establishment in recipients of a state of immunologic tolerance toward grafted hematopoietic stem cells (HSCs) remarkably improves the clinical outcome of this transplant procedure in terms of overall and disease free survival. However, the HLA-mismatch between donors and recipients has not been yet fully exploited in order to optimize the Graft vs. Leukemia effect. Furthermore, the efficacy of haplo-HSCT is currently hampered by several life-threatening side effects including the onset of Graft vs. Host Disease (GvHD) and the occurrence of opportunistic viral infections. In this context, the quality and the kinetic of the immune cell reconstitution (IR) certainly play a major role and several experimental efforts have been greatly endorsed to better understand and accelerate the post-transplant recovery of a fully competent immune system in haplo-HSCT. In particular, the IR of innate immune system is receiving a growing interest, as it recovers much earlier than T and B cells and it is able to rapidly exert protective effects against both tumor relapses, GvHD and the onset of life-threatening opportunistic infections. Herein, we review our current knowledge in regard to the kinetic and clinical impact of Natural Killer (NK), γδ and Innate lymphoid cells (ILCs) IRs in both allogeneic and haplo-HSCT. The present paper also provides an overview of those new therapeutic strategies currently being implemented to boost the alloreactivity of the above-mentioned innate immune effectors in order to ameliorate the prognosis of patients affected by hematologic malignancies and undergone transplant procedures.
Identifiants
pubmed: 31849972
doi: 10.3389/fimmu.2019.02794
pmc: PMC6892976
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2794Informations de copyright
Copyright © 2019 Zaghi, Calvi, Di Vito and Mavilio.
Références
Immunol Lett. 2013 Sep-Oct;155(1-2):11-3
pubmed: 24076315
Semin Immunol. 2014 Apr;26(2):138-44
pubmed: 24629893
Nat Rev Drug Discov. 2014 Jan;13(1):21-38
pubmed: 24378801
Cancer Immunol Res. 2018 Apr;6(4):467-480
pubmed: 29459477
Cell. 2014 Apr 10;157(2):340-356
pubmed: 24725403
Hum Gene Ther. 1999 May 20;10(8):1359-73
pubmed: 10365666
Biol Blood Marrow Transplant. 2014 Apr;20(4):440-9
pubmed: 24315844
Cytokine Growth Factor Rev. 2018 Aug;42:5-12
pubmed: 29454785
Blood. 2003 Nov 1;102(9):3427-38
pubmed: 12869514
Haematologica. 2015 Feb;100(2):e42-5
pubmed: 25344527
Cell Rep. 2016 May 3;15(5):1088-1099
pubmed: 27117418
Medicine (Baltimore). 2009 Nov;88(6):322-30
pubmed: 19910746
Blood. 1991 Jan 15;77(2):393-9
pubmed: 1845932
N Engl J Med. 2017 Nov 30;377(22):2167-2179
pubmed: 29171820
Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S24-30
pubmed: 26039203
Front Immunol. 2018 Feb 15;9:283
pubmed: 29497427
Biol Blood Marrow Transplant. 2012 Dec;18(12):1835-44
pubmed: 22796535
Biol Blood Marrow Transplant. 2010 May;16(5):612-21
pubmed: 20139023
Biol Blood Marrow Transplant. 2014 May;20(5):655-61
pubmed: 24462981
Haematologica. 2015 Aug;100(8):e332-3
pubmed: 26314084
Blood. 2010 Sep 23;116(12):2164-72
pubmed: 20576814
Biol Blood Marrow Transplant. 2011 Aug;17(8):1169-75
pubmed: 21126598
Cell Immunol. 2015 Jul;296(1):31-40
pubmed: 25991474
Immunol Rev. 2006 Dec;214:143-54
pubmed: 17100882
Haematologica. 2018 Aug;103(8):1390-1402
pubmed: 29700172
Nat Immunol. 2016 Mar;17(3):269-76
pubmed: 26779601
Blood. 2011 Jan 20;117(3):764-71
pubmed: 20889923
Cancer Immunol Immunother. 2008 Mar;57(3):411-23
pubmed: 17717662
Oncoimmunology. 2016 Sep 9;5(10):e1226720
pubmed: 27853650
Oncotarget. 2017 Jan 3;8(1):51-63
pubmed: 27980216
J Leukoc Biol. 2019 Jun;105(6):1243-1251
pubmed: 30645023
Leuk Res. 2015 Dec;39(12):1334-41
pubmed: 26422556
Science. 2015 Nov 20;350(6263):981-5
pubmed: 26472762
Blood. 2011 Jul 28;118(4):992-1001
pubmed: 21633088
Blood. 2018 Jan 11;131(2):247-262
pubmed: 28986344
Clin Cancer Res. 2007 May 15;13(10):2916-22
pubmed: 17504991
Front Immunol. 2016 May 18;7:188
pubmed: 27242795
Science. 2011 Jan 7;331(6013):44-9
pubmed: 21212348
Nature. 1998 Feb 19;391(6669):795-9
pubmed: 9486650
Nature. 2015 Dec 24;528(7583):560-564
pubmed: 26649819
Clin Transplant. 2018 Jan;32(1):
pubmed: 29090489
Curr Top Microbiol Immunol. 2016;395:63-94
pubmed: 26472216
Clin Microbiol Rev. 2009 Jan;22(1):76-98, Table of Contents
pubmed: 19136435
Nat Rev Immunol. 2013 Feb;13(2):145-9
pubmed: 23348417
Front Immunol. 2019 Apr 30;10:957
pubmed: 31114587
Immunity. 2015 Oct 20;43(4):634-45
pubmed: 26488815
Eur J Immunol. 2016 May;46(5):1271-8
pubmed: 26840535
Eur J Immunol. 2015 Aug;45(8):2171-82
pubmed: 26031799
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Retrovirology. 2013 Dec 18;10:158
pubmed: 24351015
Int J Mol Sci. 2016 Oct 27;17(11):
pubmed: 27801784
Blood. 2019 Apr 11;133(15):1652-1663
pubmed: 30728140
Annu Rev Med. 2003;54:29-52
pubmed: 12359826
J Transl Med. 2016 Sep 13;14:264
pubmed: 27620209
Blood. 2012 Nov 22;120(22):4324-33
pubmed: 23033266
Biol Blood Marrow Transplant. 2016 Dec;22(12):2187-2193
pubmed: 27664326
Haematologica. 2016 May;101(5):626-33
pubmed: 26721894
Immunol Rev. 2006 Dec;214:56-72
pubmed: 17100876
Expert Opin Biol Ther. 2008 May;8(5):583-97
pubmed: 18407763
Trends Immunol. 2010 Nov;31(11):401-6
pubmed: 20829113
Blood. 2002 Sep 15;100(6):1935-47
pubmed: 12200350
Immunol Rev. 2006 Dec;214:73-91
pubmed: 17100877
Front Immunol. 2014 Nov 20;5:601
pubmed: 25477886
Leukemia. 2013 Jun;27(6):1328-38
pubmed: 23277330
Adv Immunol. 2010;108:21-44
pubmed: 21056728
Eur J Immunol. 2008 Nov;38(11):2934-7
pubmed: 18979511
Immunol Rev. 2015 Sep;267(1):178-96
pubmed: 26284478
Nat Rev Clin Oncol. 2012 Sep;9(9):510-9
pubmed: 22801669
Front Immunol. 2018 May 07;9:984
pubmed: 29867961
Cell. 2017 Nov 2;171(4):795-808.e12
pubmed: 29056343
Haematologica. 2015 Jul;100(7):e257-60
pubmed: 25710455
Nat Immunol. 2016 Jan;17(1):65-75
pubmed: 26595887
Nat Immunol. 2016 Jun 21;17(7):765-74
pubmed: 27328006
Haematologica. 2015 Jan;100(1):114-23
pubmed: 25261095
Immunity. 2018 Jun 19;48(6):1104-1117
pubmed: 29924976
Blood. 2010 Nov 18;116(20):4360-7
pubmed: 20625005
Immunity. 2014 Sep 18;41(3):354-365
pubmed: 25238093
Nat Immunol. 2016 Nov;17(11):1291-1299
pubmed: 27618553
Blood. 2004 Dec 1;104(12):3664-71
pubmed: 15304389
Blood. 2016 Sep 29;128(13):1688-700
pubmed: 27412889
Immunity. 2013 Jun 27;38(6):1223-35
pubmed: 23791642
Eur J Immunol. 2018 Feb;48(2):316-329
pubmed: 28944953
Curr Opin Immunol. 2017 Apr;45:73-81
pubmed: 28236750
Front Immunol. 2017 Feb 10;8:109
pubmed: 28239380
Curr Opin Immunol. 2005 Jun;17(3):306-11
pubmed: 15886122
Microbes Infect. 2002 Dec;4(15):1545-58
pubmed: 12505527
Bone Marrow Transplant. 1992 Sep;10(3):249-53
pubmed: 1422478
J Exp Med. 2005 May 16;201(10):1567-78
pubmed: 15897274
Blood. 2008 Aug 1;112(3):461-9
pubmed: 18650461
Immunol Rev. 2019 Jul;290(1):100-113
pubmed: 31355496
Nat Rev Immunol. 2015 Nov;15(11):683-91
pubmed: 26449179
Biol Blood Marrow Transplant. 2015 Mar;21(3):429-39
pubmed: 25579888
Bone Marrow Transplant. 2003 May;31(9):803-8
pubmed: 12732888
J Clin Invest. 2014 Dec;124(12):5305-16
pubmed: 25384219
Bone Marrow Transplant. 2000 Jul;26(2):177-85
pubmed: 10918428
Bone Marrow Transplant. 2015 Feb;50(2):317-9
pubmed: 25419693
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1210-5
pubmed: 22167808
Biol Blood Marrow Transplant. 2018 Jun;24(6):1152-1162
pubmed: 29505821
Br J Haematol. 2004 Aug;126(4):583-92
pubmed: 15287953
Blood. 2011 Aug 4;118(5):1402-12
pubmed: 21540462
Transpl Infect Dis. 2015 Apr;17(2):242-9
pubmed: 25648539
Front Immunol. 2019 Aug 02;10:1812
pubmed: 31428098
Semin Immunol. 2017 Jun;31:55-63
pubmed: 28943093
Nat Rev Immunol. 2002 May;2(5):336-45
pubmed: 12033739
Biol Blood Marrow Transplant. 2019 Jan;25(1):1-11
pubmed: 30142416
Front Immunol. 2018 May 15;9:1050
pubmed: 29868012
Bone Marrow Transplant. 2013 Oct;48(10):1313-6
pubmed: 23562969
Blood. 2011 Sep 1;118(9):2609-17
pubmed: 21715313
Front Immunol. 2017 Apr 25;8:465
pubmed: 28487696
PLoS Pathog. 2014 Oct 16;10(10):e1004441
pubmed: 25329659
Semin Immunol. 2019 Feb;41:101272
pubmed: 31085114
J Clin Immunol. 2012 Apr;32(2):268-80
pubmed: 22173879
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2886-91
pubmed: 15699323
Annu Rev Immunol. 2005;23:225-74
pubmed: 15771571
Pathol Res Pract. 2012 Feb 15;208(2):67-73
pubmed: 22115749
Biol Blood Marrow Transplant. 2015 Jan;21(1):130-6
pubmed: 25445640
Eur J Immunol. 2004 Jan;34(1):81-90
pubmed: 14971033
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
Nat Med. 2018 Jan;24(1):20-28
pubmed: 29155426
Cytotherapy. 1999;1(1):7-19
pubmed: 19746645
Nat Immunol. 2017 Apr;18(4):393-401
pubmed: 28218745
Biol Blood Marrow Transplant. 2013 Jan;19(1):117-22
pubmed: 22940057
J Exp Med. 1994 Aug 1;180(2):545-55
pubmed: 8046333
Blood. 2018 Mar 8;131(10):1063-1072
pubmed: 29358176
Immunity. 2012 Aug 24;37(2):339-50
pubmed: 22921121
Haematologica. 2011 Mar;96(3):400-7
pubmed: 21109686
Semin Hematol. 2019 Jul;56(3):221-226
pubmed: 31202434
Eur J Immunol. 2019 Jan;49(1):11-18
pubmed: 30350853
J Gen Virol. 2006 Jul;87(Pt 7):1763-79
pubmed: 16760381
PLoS Pathog. 2008 Jul 11;4(7):e1000101
pubmed: 18617991
Immunol Cell Biol. 2014 Mar;92(3):221-9
pubmed: 24366519
Blood Rev. 2016 May;30(3):179-88
pubmed: 26654098
Biol Blood Marrow Transplant. 2011 Feb;17(2):205-13
pubmed: 20736080
Haematologica. 2017 Nov;102(11):1810-1822
pubmed: 28883081
Virulence. 2016 Nov 16;7(8):967-980
pubmed: 27580355
Nat Med. 2017 Aug;23(8):938-944
pubmed: 28714991
Bone Marrow Transplant. 2019 Aug;54(Suppl 2):785-788
pubmed: 31431708
J Immunol. 2016 Mar 1;196(5):2051-2062
pubmed: 26826243
Blood. 2013 Apr 4;121(14):2678-88
pubmed: 23325834
Nat Immunol. 2018 May;19(5):453-463
pubmed: 29632329
Clin Immunol. 2009 Nov;133(2):171-8
pubmed: 19481979
Front Immunol. 2018 Mar 22;9:505
pubmed: 29623077
Blood. 2011 Dec 1;118(23):6050-6
pubmed: 21984804
J Hematother. 1996 Oct;5(5):503-9
pubmed: 8938522
Front Immunol. 2012 Dec 21;3:374
pubmed: 23267359
Clin Infect Dis. 2014 Aug 15;59(4):473-81
pubmed: 24850801
Cytometry B Clin Cytom. 2018 May;94(3):392-399
pubmed: 29244250
Bone Marrow Transplant. 2016 May;51(5):668-74
pubmed: 26808573
Trends Immunol. 2001 Nov;22(11):633-40
pubmed: 11698225
Nat Immunol. 2016 Feb;17(2):179-86
pubmed: 26595889
Front Immunol. 2016 Dec 22;7:595
pubmed: 28066411
Blood. 2010 May 27;115(21):4293-301
pubmed: 20233969
Nature. 2000 Nov 2;408(6808):57-63
pubmed: 11081504
J Immunol. 2012 Nov 15;189(10):5082-8
pubmed: 23077239
Blood. 2017 Aug 3;130(5):677-685
pubmed: 28588018
Mol Med Rep. 2019 Mar;19(3):1471-1480
pubmed: 30628681
Rev Med Virol. 2016 Mar;26(2):75-89
pubmed: 26572645
J Immunol. 2002 Nov 1;169(9):5118-29
pubmed: 12391228
PLoS Pathog. 2013 Sep;9(9):e1003615
pubmed: 24068930
Blood. 2012 Mar 15;119(11):2665-74
pubmed: 22180440
Blood. 2014 Jul 31;124(5):812-21
pubmed: 24855210
Cytotherapy. 2012 Aug;14(7):830-40
pubmed: 22458956
Front Immunol. 2015 Nov 09;6:573
pubmed: 26617607
Blood. 2005 Jul 1;106(1):376-83
pubmed: 15755898
Bone Marrow Transplant. 2007 Jun;39(12):751-7
pubmed: 17450185
J Immunol. 2013 Feb 15;190(4):1402-6
pubmed: 23345329
J Infect Dis. 2002 Feb 1;185(3):273-82
pubmed: 11807708
Oncotarget. 2016 Dec 27;7(52):86359-86373
pubmed: 27861156
Leukemia. 2018 Feb;32(2):520-531
pubmed: 28725044
Front Immunol. 2014 Aug 14;5:390
pubmed: 25177322
Br J Haematol. 2017 Jun;177(5):766-781
pubmed: 28466469
Cancer Lett. 2016 Oct 1;380(2):413-23
pubmed: 27392648
Acta Pharmacol Sin. 2018 Feb;39(2):167-176
pubmed: 28880014
Biol Blood Marrow Transplant. 2008 Mar;14(3):323-34
pubmed: 18275899
Blood. 2013 Aug 15;122(7):1316-24
pubmed: 23744585
Science. 2015 May 22;348(6237):aaa6566
pubmed: 25999512
Virology. 2005 Feb 20;332(2):491-7
pubmed: 15680414
Blood. 2015 Apr 9;125(15):2349-58
pubmed: 25612623
Cell Host Microbe. 2015 Jul 8;18(1):27-37
pubmed: 26159718
Leukemia. 2008 Feb;22(2):344-52
pubmed: 18033316
Blood. 2016 Dec 8;128(23):2616-2623
pubmed: 27697774
J Immunol. 2014 Feb 15;192(4):1471-9
pubmed: 24442432
Harvey Lect. 1966-1967;62:21-78
pubmed: 4875305
Cell Mol Life Sci. 2011 Jul;68(14):2357-70
pubmed: 21560072
Blood. 2014 Jul 31;124(5):822-6
pubmed: 24869942
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10762-7
pubmed: 26243875
J Leukoc Biol. 2010 Dec;88(6):1119-30
pubmed: 20651298
Oncoimmunology. 2013 Jan 1;2(1):e22892
pubmed: 23483102
Eur J Immunol. 2013 Feb;43(2):480-7
pubmed: 23161492
Cancer Immunol Res. 2015 Apr;3(4):333-44
pubmed: 25492700
Best Pract Res Clin Haematol. 2008 Sep;21(3):579-96
pubmed: 18790456
Cancer Res. 2009 May 1;69(9):4010-7
pubmed: 19383914
Bone Marrow Transplant. 2006 Aug;38(4):291-7
pubmed: 16883312
Immunity. 2015 Mar 17;42(3):431-42
pubmed: 25786175
Immunology. 2011 Mar;132(3):315-25
pubmed: 21214544
Semin Hematol. 2016 Apr;53(2):90-7
pubmed: 27000732
Immunity. 2015 Mar 17;42(3):443-56
pubmed: 25786176
Clin Lymphoma Myeloma Leuk. 2016 Sep;16(9):527-535.e2
pubmed: 27375156
Nat Rev Immunol. 2013 Feb;13(2):88-100
pubmed: 23348415
Science. 2012 Apr 6;336(6077):91-5
pubmed: 22383805
Bone Marrow Transplant. 2016 Aug;51(8):1134-6
pubmed: 26999460
Blood. 2008 Oct 15;112(8):3488-99
pubmed: 18645039
Sci Transl Med. 2016 Sep 21;8(357):357ra123
pubmed: 27655849
Oncoimmunology. 2014 Apr 15;3:e28147
pubmed: 25340009
J Immunol. 2015 Sep 15;195(6):2818-28
pubmed: 26276870
J Clin Invest. 2008 Jan;118(1):281-93
pubmed: 18064301
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15011-6
pubmed: 14645713
Blood. 2001 Jun 1;97(11):3380-9
pubmed: 11369627
Biol Blood Marrow Transplant. 2008 Jun;14(6):641-50
pubmed: 18489989
Blood. 2015 Apr 30;125(18):2855-64
pubmed: 25742699
Int Arch Allergy Immunol. 2000 May;122(1):1-7
pubmed: 10859464
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14725-32
pubmed: 21825173
Cancer Res. 2006 Mar 15;66(6):3331-7
pubmed: 16540688
Nat Rev Immunol. 2005 Mar;5(3):201-14
pubmed: 15719024
Bone Marrow Transplant. 2009 Oct;44(8):457-62
pubmed: 19861978
Pharmacol Ther. 2003 Jun;98(3):269-97
pubmed: 12782241
J Immunol. 2009 Jun 1;182(11):7287-96
pubmed: 19454726
Haematologica. 2016 Mar;101(3):371-81
pubmed: 26659918
Nat Immunol. 2016 Jan;17(1):76-86
pubmed: 26595888
Immunity. 2013 Apr 18;38(4):769-81
pubmed: 23453631
Science. 2002 May 17;296(5571):1323-6
pubmed: 11950999
Blood. 2017 Oct 19;130(16):1857-1868
pubmed: 28835441
Acta Haematol. 2011;126(1):13-20
pubmed: 21411985
Blood. 2006 May 1;107(9):3624-31
pubmed: 16384928
Br J Haematol. 2006 Nov;135(4):524-32
pubmed: 17010105
Nat Rev Immunol. 2010 Jul;10(7):467-78
pubmed: 20539306
Clin Microbiol Infect. 2014 Feb;20(2):160-6
pubmed: 23607363
J Exp Med. 1995 Sep 1;182(3):875-84
pubmed: 7650491
Pediatr Rep. 2011 Jun 22;3 Suppl 2:e14
pubmed: 22053276
Oncoimmunology. 2016 Sep 27;6(2):e1216291
pubmed: 28344861
Curr Opin Hematol. 2012 Jul;19(4):324-35
pubmed: 22517587
Front Immunol. 2014 Apr 16;5:175
pubmed: 24795719
J Immunother Cancer. 2016 Sep 20;4:54
pubmed: 27660708
Leukemia. 2011 Jan;25(1):121-9
pubmed: 20944677
Front Immunol. 2016 Apr 15;7:144
pubmed: 27148263
Front Immunol. 2017 Dec 13;8:1818
pubmed: 29326704
J Immunol. 2019 Apr 1;202(7):1962-1969
pubmed: 30737273
J Immunol. 2007 Apr 15;178(8):4947-55
pubmed: 17404276
Leukemia. 2014 Jun;28(6):1181-90
pubmed: 24345790
J Immunol. 2011 Feb 15;186(4):1891-7
pubmed: 21289313
Ann N Y Acad Sci. 2012 Aug;1266:161-70
pubmed: 22901267
Blood. 2005 May 15;105(10):4135-42
pubmed: 15687235
Biol Blood Marrow Transplant. 2016 Feb;22(2):195-206
pubmed: 26341398
J Clin Oncol. 2005 May 20;23(15):3447-54
pubmed: 15753458
Biol Blood Marrow Transplant. 2018 Sep;24(9):1841-1847
pubmed: 29753837
Nat Rev Immunol. 2012 May 11;12(6):443-58
pubmed: 22576252
N Engl J Med. 2017 Dec 21;377(25):2433-2444
pubmed: 29211658
Front Immunol. 2017 Mar 23;8:314
pubmed: 28386256
Cell Mol Immunol. 2013 Jan;10(1):50-7
pubmed: 23064104
Blood. 2012 Nov 22;120(22):4317-23
pubmed: 23002117
Immunol Rev. 2008 Aug;224:58-69
pubmed: 18759920
Leukemia. 2007 Oct;21(10):2145-52
pubmed: 17673900
Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S6-10
pubmed: 26039210
J Transl Med. 2018 Jan 10;16(1):3
pubmed: 29316940
J Immunol Res. 2019 Feb 6;2019:8795673
pubmed: 30882007
Scand J Immunol. 2015 Jun;81(6):459-68
pubmed: 25753378
J Autoimmun. 2016 Jan;66:40-50
pubmed: 26330348
Science. 2018 Jan 5;359(6371):114-119
pubmed: 29302015
J Immunol. 2019 Apr 1;202(7):2141-2152
pubmed: 30787107
Immunol Cell Biol. 2011 Feb;89(2):216-24
pubmed: 20567250