Role of donor macrophages after heart and lung transplantation.
basic (laboratory) research/science
heart (allograft) function/dysfunction
heart disease: immune/inflammatory
heart transplantation/cardiology
immunosuppressant
immunosuppression/immune modulation
lung (allograft) function/dysfunction
lung disease: immune/inflammatory
translational research/science
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
18
10
2019
revised:
06
12
2019
accepted:
08
12
2019
pubmed:
19
12
2019
medline:
22
6
2021
entrez:
19
12
2019
Statut:
ppublish
Résumé
Since the 1960s, heart and lung transplantation has remained the optimal therapy for patients with end-stage disease, extending and improving quality of life for thousands of individuals annually. Expanding donor organ availability and immunologic compatibility is a priority to help meet the clinical demand for organ transplant. While effective, current immunosuppression is imperfect as it lacks specificity and imposes unintended adverse effects such as opportunistic infections and malignancy that limit the health and longevity of transplant recipients. In this review, we focus on donor macrophages as a new target to achieve allograft tolerance. Donor organ-directed therapies have the potential to improve allograft survival while minimizing patient harm related to global suppression of recipient immune responses. Topics highlighted include the role of ontogenically distinct donor macrophage populations in ischemia-reperfusion injury and rejection, including their interaction with allograft-infiltrating recipient immune cells and potential therapeutic approaches. Ultimately, a better understanding of how donor intrinsic immunity influences allograft acceptance and survival will provide new opportunities to improve the outcomes of transplant recipients.
Identifiants
pubmed: 31850651
doi: 10.1111/ajt.15751
pmc: PMC7202685
mid: NIHMS1583733
pii: S1600-6135(22)22308-9
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1225-1235Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL138466
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139714
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151078
Pays : United States
Informations de copyright
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.
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