The transdermal performance, pharmacokinetics, and anti-inflammatory pharmacodynamics evaluation of harmine-loaded ethosomes.
Administration, Cutaneous
Animals
Anti-Inflammatory Agents
/ administration & dosage
Area Under Curve
Disease Models, Animal
Drug Delivery Systems
Edema
/ drug therapy
Fibroblasts
/ drug effects
Harmine
/ administration & dosage
Humans
Inflammation
/ drug therapy
Liposomes
Rats
Rats, Sprague-Dawley
Skin
/ metabolism
Skin Absorption
Harmine
anti-inflammatory
ethosomes
pharmacokinetics
skin deposition
Journal
Drug development and industrial pharmacy
ISSN: 1520-5762
Titre abrégé: Drug Dev Ind Pharm
Pays: England
ID NLM: 7802620
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
pubmed:
19
12
2019
medline:
30
10
2020
entrez:
19
12
2019
Statut:
ppublish
Résumé
Harmine (HAR) is a β-carboline alkaloid with anti-inflammatory and antipruritic effect. However, the low bioavailability and side effects of HAR severely limited its clinical application. The main objective of this study was to develop harmine-loaded ethosomes (HLE) drug delivery system for topical application to treat inflammation. HLE were obtained by ethanol injection method and characterized. The morphology of HLE was evaluated by transmission electron microscopy (TEM). HLE exhibited a good biocompatibility with human embryonic skin fibroblasts and rat skin. The
Identifiants
pubmed: 31851523
doi: 10.1080/03639045.2019.1706549
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Liposomes
0
Harmine
4FHH5G48T7
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM