Circulating microRNA after autologous bone marrow mononuclear cell (BM-MNC) injection in patients with ischemic stroke.
adult human bone marrow
clinical trial
microRNAs
stroke
transplantation
Journal
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
ISSN: 1708-8267
Titre abrégé: J Investig Med
Pays: England
ID NLM: 9501229
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
accepted:
28
11
2019
pubmed:
20
12
2019
medline:
14
7
2021
entrez:
20
12
2019
Statut:
ppublish
Résumé
Previous studies have shown the potential of microRNAs (miRNA) in the pathological process of stroke and functional recovery. Bone marrow mononuclear cell (BM-MNC) transplantation improves recovery in experimental models of ischemic stroke that might be related with miRNA modifications. However, its effect on circulating miRNA has not been described in patients with stroke. We aimed to evaluate the circulating levels of miRNAs after autologous BM-MNC transplantation in patients with stroke. We investigate the pattern of miRNA-133b and miRNA-34a expression in patients with ischemic stroke included in a multicenter randomized controlled phase IIb trial (http://www.clinicaltrials.gov; unique identifier: NCT02178657). Patients were randomized to 2 different doses of autologous intra-arterial BM-MNC injection (2×10
Identifiants
pubmed: 31852749
pii: jim-2019-001161
doi: 10.1136/jim-2019-001161
doi:
Substances chimiques
Circulating MicroRNA
0
Banques de données
ClinicalTrials.gov
['NCT02178657']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
807-810Informations de copyright
© American Federation for Medical Research 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.