pK


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
18 12 2019
Historique:
received: 17 07 2019
accepted: 03 12 2019
entrez: 20 12 2019
pubmed: 20 12 2019
medline: 11 11 2020
Statut: epublish

Résumé

The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-derived μ-opioid receptor (MOR) agonists with reduced acid dissociation constants (pK

Identifiants

pubmed: 31852967
doi: 10.1038/s41598-019-55886-1
pii: 10.1038/s41598-019-55886-1
pmc: PMC6920366
doi:

Substances chimiques

Analgesics, Opioid 0
Ligands 0
Piperidines 0
Receptors, Opioid, mu 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

19344

Commentaires et corrections

Type : ErratumIn

Références

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Auteurs

Giovanna Del Vecchio (G)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.

Dominika Labuz (D)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.

Julia Temp (J)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.

Viola Seitz (V)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.

Michael Kloner (M)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.

Roger Negrete (R)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.

Antonio Rodriguez-Gaztelumendi (A)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.
Department of Drug Discovery and In Vitro Pharmacology, Laboratorios Dr. Esteve, Parc Científic de Barcelona, Baldiri Reixac 4-12, Barcelona, Spain.

Marcus Weber (M)

Zuse Institute Berlin, Computational Molecular Design, Takustraße 7, 14195, Berlin, Germany.

Halina Machelska (H)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany.

Christoph Stein (C)

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Experimental Anesthesiology, Hindenburgdamm 30, 12203, Berlin, Germany. Christoph.stein@charite.de.

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Classifications MeSH