Pulmonary Atypical Adenomatous Hyperplasia: Diagnostic and Therapeutic Implications.
adenocarcinoma
atypical adenomatous hyperplasia
bronchioloalveolar carcinoma
pulmonary aah
stereotactic body radiotherapy
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
05 Nov 2019
05 Nov 2019
Historique:
entrez:
20
12
2019
pubmed:
20
12
2019
medline:
20
12
2019
Statut:
epublish
Résumé
Lung cancer still remains one of the most common cancers throughout the world, especially in smokers. Adenocarcinoma is now the predominant histological type in many western countries. The etiology of adenocarcinoma is unknown, but evidence suggests that atypical adenomatous hyperplasia (AAH) may act as a precursor lesion. Here we present two case reports of patients diagnosed with AAH on biopsy, highlighting 1) available treatment strategies and 2) AAH's progression to adenocarcinoma. A review of AAH is warranted as little literature is currently available regarding its treatment strategies, especially in light of its role as a precursor to adenocarcinoma. In this review, we will address the following topics: 1. What is the pathophysiology of AAH? 2. What is the natural history of AAH and its risk of malignant transformation? 3. When is surgery recommended? 4. What is the role of stereotactic body radiotherapy (SBRT) in the rare patient who refuses surgery?
Identifiants
pubmed: 31853430
doi: 10.7759/cureus.6079
pmc: PMC6894895
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e6079Informations de copyright
Copyright © 2019, Nguyen et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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