Regulatory T Cells in Severe Persistent Asthma in the Era of Monoclonal Antibodies Target Therapies.
Biological therapy
Regulatory T cells
Severe asthma
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
pubmed:
20
12
2019
medline:
9
2
2021
entrez:
20
12
2019
Statut:
ppublish
Résumé
Asthma is an immunoinflammatory disease characterized by bronchial hyper-reactivity to different external stimuli. New monoclonal target treatments have been developed, but few studies have investigated the role of regulatory T cells in severe asthma and the modulatory effect of biological therapy on regulatory T cell functions. Their dysfunction may contribute to the development and exacerbation of asthma. Here we review the recent literature on the potential immunological role of regulatory T cells in the pathogenesis of severe asthma. The analysis of the role of regulatory T cells was performed in terms of functions and their possible interactions with mechanisms of action of the novel treatment for severe asthma. In an era of biological therapies for severe asthma, little data is available on the potential effects of what could be a new therapy: monoclonal antibody targeting of regulatory T cell numbers and functions.
Identifiants
pubmed: 31853715
doi: 10.1007/s10753-019-01157-0
pii: 10.1007/s10753-019-01157-0
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Antibodies, Monoclonal, Humanized
0
Daclizumab
CUJ2MVI71Y
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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