Pulmonary non-tuberculous mycobacterial infections: current state and future management.
Diagnosis
Environmental factors
Host factors
Pulmonary non-tuberculous mycobacterial
Treatment
Vaccine
Virulence factors
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
11
08
2019
accepted:
18
11
2019
pubmed:
20
12
2019
medline:
15
12
2020
entrez:
20
12
2019
Statut:
ppublish
Résumé
Currently, there is a trend of increasing incidence in pulmonary non-tuberculous mycobacterial infections (PNTM) together with a decrease in tuberculosis (TB) incidence, particularly in developed countries. The prevalence of PNTM in underdeveloped and developing countries remains unclear as there is still a lack of detection methods that could clearly diagnose PNTM applicable in these low-resource settings. Since non-tuberculous mycobacteria (NTM) are environmental pathogens, the vicinity favouring host-pathogen interactions is known as important predisposing factor for PNTM. The ongoing changes in world population, as well as socio-political and economic factors, are linked to the rise in the incidence of PNTM. Development is an important factor for the improvement of population well-being, but it has also been linked, in general, to detrimental environmental consequences, including the rise of emergent (usually neglected) infectious diseases, such as PNTM. The rise of neglected PNTM infections requires the expansion of the current efforts on the development of diagnostics, therapies and vaccines for mycobacterial diseases, which at present, are mainly focused on TB. This review discuss the current situation of PNTM and its predisposing factors, as well as the efforts and challenges for their control.
Identifiants
pubmed: 31853742
doi: 10.1007/s10096-019-03771-0
pii: 10.1007/s10096-019-03771-0
pmc: PMC7222044
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
799-826Subventions
Organisme : Universiti Malaysia Sabah
ID : SLB0172-2018
Organisme : Kementerian Pendidikan Malaysia
ID : 203.PPSK.67212002
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