An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine.

Antioxidants / pharmacology Chelating Agents / pharmacology Copper Hydroquinones Oxidation-Reduction Penicillamine Pharmaceutical Preparations
Antioxidant-like activity Autooxidation Penicillamine Redox reaction Tetrachlorohydroquinone Tetrachlorosemiquinone radical

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
01 02 2020
Historique:
received: 09 10 2019
revised: 30 11 2019
accepted: 14 12 2019
pubmed: 21 12 2019
medline: 22 6 2021
entrez: 21 12 2019
Statut: ppublish

Résumé

Penicillamine has been widely-used clinically as a copper-chelating drug for the treatment of copper-overload in Wilson's disease. In this study, we found that penicillamine provided marked protection against cytotoxicity induced by tetrachlorohydroquinone (TCHQ), a major toxic metabolite of the well-known wood preservative pentachlorophenol, while other classic copper-chelating agents do not. We found, unexpectedly, that both TCHQ autooxidation and tetrachlorosemiquinone radical (TCSQ

Identifiants

DOI: 10.1016/j.freeradbiomed.2019.12.013 PMID: 31857235
pubmed: 31857235
pii: S0891-5849(19)31686-7
doi: 10.1016/j.freeradbiomed.2019.12.013
pii:
doi:

Substances chimiques

Antioxidants 0
Chelating Agents 0
Hydroquinones 0
Pharmaceutical Preparations 0
Copper 789U1901C5
Penicillamine GNN1DV99GX

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

150-158

Informations de copyright

Copyright © 2019. Published by Elsevier Inc.

Auteurs

Li Mao (L)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.

Chun-Hua Huang (CH)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.

Jie Shao (J)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.

Li Qin (L)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.

Dan Xu (D)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.

Bo Shao (B)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China.

Ben-Zhan Zhu (BZ)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA; Joint Institute for Environmental Science, Research Center for Eco-Environmental Sciences and Hong Kong Baptist University, Beijing, Hong Kong, PR China. Electronic address: bzhu@rcees.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › An unexpected antioxidant and redox activity...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents séquestrants › Chélateurs › An unexpected antioxidant and redox activity...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › An unexpected antioxidant and redox activity...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hydroquinones › An unexpected antioxidant and redox activity...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › An unexpected antioxidant and redox activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Pénicillamine › An unexpected antioxidant and redox activity...
questionsmedicales.fr › Préparations pharmaceutiques › An unexpected antioxidant and redox activity...