Helix 8 is the essential structural motif of mechanosensitive GPCRs.
Animals
Cell Membrane
/ physiology
Endothelium, Vascular
/ cytology
Gene Knockdown Techniques
HEK293 Cells
Human Umbilical Vein Endothelial Cells
Humans
Male
Mechanotransduction, Cellular
/ physiology
Mice
Mice, Knockout
Muscle, Smooth
/ cytology
Mutagenesis, Site-Directed
Myography
Protein Conformation, alpha-Helical
/ physiology
Receptors, Histamine H1
/ physiology
Stress, Mechanical
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 12 2019
19 12 2019
Historique:
received:
02
05
2019
accepted:
19
11
2019
entrez:
21
12
2019
pubmed:
21
12
2019
medline:
9
4
2020
Statut:
epublish
Résumé
G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but also serve as mechanosensors involved in various (patho)physiological settings like vascular regulation, cardiac hypertrophy and preeclampsia. However, the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here we show that mechanosensitive histamine H
Identifiants
pubmed: 31857598
doi: 10.1038/s41467-019-13722-0
pii: 10.1038/s41467-019-13722-0
pmc: PMC6923424
doi:
Substances chimiques
Receptors, Histamine H1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5784Commentaires et corrections
Type : CommentIn
Références
Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1218-23
pubmed: 15706045
Mol Pharmacol. 2012 Aug;82(2):236-45
pubmed: 22564786
Nat Cell Biol. 2004 Jun;6(6):499-506
pubmed: 15146194
Vasc Med. 2011 Oct;16(5):365-77
pubmed: 22003002
Ann Biomed Eng. 2005 Dec;33(12):1714-8
pubmed: 16389518
Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1138-1139
pubmed: 27797720
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15463-8
pubmed: 17030791
Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):121-6
pubmed: 25395620
Cell. 2018 Apr 19;173(3):762-775.e16
pubmed: 29677517
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13666-71
pubmed: 20639466
Nature. 2011 Jun 22;475(7354):65-70
pubmed: 21697825
Hellenic J Cardiol. 2005 Jan-Feb;46(1):9-15
pubmed: 15807389
Nature. 1999 Jan 21;397(6716):259-63
pubmed: 9930701
J Cell Sci. 2013 Mar 1;126(Pt 5):1227-34
pubmed: 23378020
J Physiol. 2005 Mar 1;563(Pt 2):633-42
pubmed: 15618271
Naunyn Schmiedebergs Arch Pharmacol. 2015 Mar;388(3):363-80
pubmed: 25432095
Science. 2011 Apr 15;332(6027):322-7
pubmed: 21393508
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13316-20
pubmed: 8917588
Physiology (Bethesda). 2014 Sep;29(5):343-60
pubmed: 25180264
Circ Res. 1978 Nov;43(5):738-49
pubmed: 709740
Exp Physiol. 2011 Jul;96(7):664-73
pubmed: 21478258
Am J Physiol Heart Circ Physiol. 2012 Mar 15;302(6):H1241-9
pubmed: 22227128
Am J Physiol Cell Physiol. 2009 Jun;296(6):C1391-9
pubmed: 19369447
Science. 2010 Nov 19;330(6007):1066-71
pubmed: 20929726
Am J Physiol. 1994 Sep;267(3 Pt 1):C753-8
pubmed: 7943204
Curr Hypertens Rep. 2010 Aug;12(4):267-75
pubmed: 20532699
Cell. 2019 Jan 10;176(1-2):318-333.e19
pubmed: 30503206
Am J Physiol. 1990 Oct;259(4 Pt 2):H1063-70
pubmed: 2221113
Pflugers Arch. 2010 May;459(6):793-806
pubmed: 20012875
Blood Vessels. 1986;23(4-5):183-98
pubmed: 3779108
J Biol Chem. 2015 Nov 6;290(45):27311-20
pubmed: 26408198
Am J Physiol. 1991 Dec;261(6 Pt 2):H2016-23
pubmed: 1721502
Am J Physiol Cell Physiol. 2006 Jun;290(6):C1633-9
pubmed: 16436471
Nat Methods. 2005 Mar;2(3):171-6
pubmed: 15782185
J Biol Chem. 1998 Jan 16;273(3):1324-8
pubmed: 9430664
Nature. 1993 May 20;363(6426):274-6
pubmed: 8387644
Nat Med. 2008 Jan;14(1):64-8
pubmed: 18084302
Nat Commun. 2016 Jun 01;7:11805
pubmed: 27248505
J Biol Chem. 1985 Mar 25;260(6):3440-50
pubmed: 3838314
Cell. 2012 Sep 28;151(1):14-23
pubmed: 23021212
J Clin Invest. 2019 Jun 17;129(7):2775-2791
pubmed: 31205027
Nature. 2018 Mar 8;555(7695):269-273
pubmed: 29466326
Am J Physiol. 1994 Mar;266(3 Pt 1):C628-36
pubmed: 8166225
Am J Physiol Cell Physiol. 2019 May 1;316(5):C741-C752
pubmed: 30811222
J Immunol. 2013 Jul 15;191(2):614-22
pubmed: 23772030
J Biol Chem. 2014 Oct 3;289(40):27825-35
pubmed: 25122759
Pflugers Arch. 2014 Jul;466(7):1343-53
pubmed: 24101294
Dev Cell. 2012 Sep 11;23(3):600-10
pubmed: 22975328
Antioxid Redox Signal. 2016 Sep 1;25(7):373-88
pubmed: 27027326
Physiol Rev. 1999 Apr;79(2):387-423
pubmed: 10221985
Pflugers Arch. 2010 May;459(6):807-16
pubmed: 20082095
Am J Physiol. 1993 Feb;264(2 Pt 2):H653-9
pubmed: 8447477
J Physiol. 2017 Jul 15;595(14):4735-4753
pubmed: 28475214
EMBO J. 2008 Dec 3;27(23):3092-103
pubmed: 18987636
Microcirculation. 2016 Nov;23(8):621-625
pubmed: 27344060
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1536-41
pubmed: 23297214
EMBO Rep. 2008 Feb;9(2):179-86
pubmed: 18202720
Hypertension. 2011 Aug;58(2):325-31
pubmed: 21709211
Mol Pharmacol. 2005 Apr;67(4):1045-52
pubmed: 15626750
BMC Biol. 2011 May 27;9:32
pubmed: 21619590
Nat Rev Drug Discov. 2017 Dec;16(12):829-842
pubmed: 29075003
Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1178-85
pubmed: 26297225
Sci Signal. 2015 Nov 03;8(401):ra110
pubmed: 26535008
Int J Mol Sci. 2016 Nov 18;17(11):
pubmed: 27869740
J Clin Invest. 2016 Dec 1;126(12):4527-4536
pubmed: 27797339
Nature. 2006 Nov 2;444(7115):106-9
pubmed: 17065983
Structure. 2016 Jun 7;24(6):997-1007
pubmed: 27210286
Eur J Pharmacol. 1988 Mar 29;148(2):161-9
pubmed: 3288482
J Am Soc Nephrol. 2016 Mar;27(3):848-62
pubmed: 26160898