SHBG141-161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and β-Langerhans cell lines.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 12 2019
19 12 2019
Historique:
received:
10
07
2019
accepted:
30
09
2019
entrez:
21
12
2019
pubmed:
21
12
2019
medline:
11
11
2020
Statut:
epublish
Résumé
GPRC6A is acknowledged as a major regulator of energy metabolism and male fertility through the action of undercarboxylated osteocalcin (ucOCN), representing a possible therapeutic target. We recently showed that the sex hormone-binding globulin (SHBG) binds to GPRC6A through the likely involvement of the 141-161 domain. To confirm this model, here we investigated the possible binding and agonist activity of SHBG(141-161) domain-peptide (SHBG
Identifiants
pubmed: 31857654
doi: 10.1038/s41598-019-55941-x
pii: 10.1038/s41598-019-55941-x
pmc: PMC6923452
doi:
Substances chimiques
GPRC6A protein, human
0
Peptides
0
Receptors, G-Protein-Coupled
0
Sex Hormone-Binding Globulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19432Références
Trends Pharmacol Sci. 2019 Feb;40(2):142-153
pubmed: 30616873
Biochemistry. 2002 Nov 19;41(46):13556-69
pubmed: 12427016
Drug Discov Today. 2018 Sep;23(9):1591-1595
pubmed: 29649573
Recent Prog Horm Res. 1982;38:457-510
pubmed: 6750727
Life Sci. 2003 Oct 17;73(22):2855-63
pubmed: 14511770
Endocrinology. 2016 Nov;157(11):4473-4486
pubmed: 27673554
Clin Chim Acta. 1977 Oct 1;80(1):171-80
pubmed: 561671
Endocrinology. 1998 Jun;139(6):2960-70
pubmed: 9607807
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Curr Opin Neurobiol. 2001 Jun;11(3):312-9
pubmed: 11399429
Biochemistry. 1996 Sep 3;35(35):11503-11
pubmed: 8784206
Cell Physiol Biochem. 2011;28(2):355-66
pubmed: 21865744
EMBO J. 2000 Feb 15;19(4):504-12
pubmed: 10675319
Nat Rev Drug Discov. 2019 Jan;18(1):19-40
pubmed: 30498202
Mol Endocrinol. 2015 Dec;29(12):1759-73
pubmed: 26440882
J Biol Chem. 1995 Sep 22;270(38):22488-99
pubmed: 7673239
Diabetes. 2000 Mar;49(3):424-30
pubmed: 10868964
Endocrinology. 2014 Nov;155(11):4266-74
pubmed: 25093461
Nat Struct Biol. 2002 Jun;9(6):408-10
pubmed: 12032551
J Biol Chem. 2010 Dec 17;285(51):39953-64
pubmed: 20947496
Steroids. 2019 Feb;142:100-108
pubmed: 30707908
Cell. 2016 Mar 10;164(6):1248-1256
pubmed: 26967290
J Neuroimmunol. 2004 Nov;156(1-2):178-87
pubmed: 15465609
J Neurochem. 2005 Apr;93(2):383-91
pubmed: 15816861
Sci Rep. 2016 Aug 18;6:32153
pubmed: 27535582
Mol Metab. 2016 Dec 21;6(2):185-193
pubmed: 28180060
J Bone Miner Res. 2011 Jul;26(7):1680-3
pubmed: 21425331
Endocrinology. 2002 Mar;143(3):1026-35
pubmed: 11861529
N Engl J Med. 2009 Sep 17;361(12):1152-63
pubmed: 19657112
Mol Nutr Food Res. 2018 Apr;62(8):e1700770
pubmed: 29468843
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W294-7
pubmed: 22649060
J Clin Invest. 2013 Jun;123(6):2421-33
pubmed: 23728177
Mol Biol Rep. 2019 Oct;46(5):4953-4965
pubmed: 31270755
Biopolymers. 1987 Sep;26(9):1587-600
pubmed: 3663874
PLoS One. 2018 Apr 23;13(4):e0195980
pubmed: 29684031
Front Biosci (Landmark Ed). 2014 Jun 01;19:1105-16
pubmed: 24896339
Bioinformatics. 2016 Dec 1;32(23):3676-3678
pubmed: 27503228
Mol Pharmacol. 2006 Nov;70(5):1783-91
pubmed: 16926282
Cell. 2011 Mar 4;144(5):796-809
pubmed: 21333348
Science. 1990 Nov 2;250(4981):646-51
pubmed: 2237415
Neurobiol Aging. 2008 Jun;29(6):926-36
pubmed: 17258840
Cell. 2010 Jul 23;142(2):296-308
pubmed: 20655470
J Chem Theory Comput. 2014 Oct 14;10(10):4745-58
pubmed: 26588162
Mol Pharmacol. 2005 Mar;67(3):589-97
pubmed: 15576628
Endocrinology. 2012 Oct;153(10):4608-15
pubmed: 22872579