Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.
Journal
Laboratory investigation; a journal of technical methods and pathology
ISSN: 1530-0307
Titre abrégé: Lab Invest
Pays: United States
ID NLM: 0376617
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
29
07
2019
accepted:
14
10
2019
revised:
09
10
2019
pubmed:
21
12
2019
medline:
21
10
2020
entrez:
21
12
2019
Statut:
ppublish
Résumé
Men and women become infertile with age, but the mechanism of declining male fertility, more specifically, the decrease in in sperm quality, is not well known. Citrate synthase (CS) is a core enzyme of the mitochondrial tricarboxylic acid (TCA) cycle, which directly controls cellular function. Extra-mitochondrial CS (eCS) is produced and abundant in the sperm head; however, its role in male fertility is unknown. We investigated the role of eCS in male fertility by producing eCs-deficient (eCs-KO) mice. The initiation of the first spike of Ca
Identifiants
pubmed: 31857692
doi: 10.1038/s41374-019-0353-3
pii: S0023-6837(22)01247-8
pmc: PMC7096335
doi:
Substances chimiques
Citrate (si)-Synthase
EC 2.3.3.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
583-595Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP19K09793
Pays : International
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18H03556
Pays : International
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP19H01067
Pays : International
Commentaires et corrections
Type : ErratumIn
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