Invariant natural killer T cells are reduced in peripheral blood of bullous pemphigoid patients and accumulate in lesional skin.
Autoantibody
Flow cytometry
Hemidesmosome
Immunofluorescence
Invariant natural killer T cells
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
27
07
2019
accepted:
11
12
2019
revised:
22
11
2019
pubmed:
21
12
2019
medline:
16
6
2021
entrez:
21
12
2019
Statut:
ppublish
Résumé
iNKT (invariant natural killer T) cells are unconventional immunoregulatory T cells which contribute to B cell maturation, antibody and cytokine production. iNKT cells are implicated in the control of autoimmune inflammation in different disorders. For bullous pemphigoid (BP), the most frequent bullous autoimmune dermatosis, the role of iNKT cells has not yet been studied. We, therefore, aimed at investigating the frequency of iNKT cells in peripheral blood and biopsies from lesional and non-lesional skin from patients with BP and controls. Circulating CD3
Identifiants
pubmed: 31858232
doi: 10.1007/s00403-019-02029-1
pii: 10.1007/s00403-019-02029-1
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
747-751Subventions
Organisme : HELIOS Kliniken
ID : HELIOS Research Support, ID 002342
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