Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila.
Drosophila
epithelia
mechanics
morphogenesis
tissue replacement
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
03 02 2020
03 02 2020
Historique:
received:
30
09
2019
revised:
30
11
2019
accepted:
06
12
2019
pubmed:
21
12
2019
medline:
8
8
2020
entrez:
21
12
2019
Statut:
ppublish
Résumé
During development, cells coordinate to organize in coherent structures. Although it is now well established that physical forces are essential for implementing this coordination, the instructive roles of mechanical inputs are not clear. Here, we show that the replacement of the larval epithelia by the adult one in Drosophila demands the coordinated exchange of mechanical signals between two cell types, the histoblasts (adult precursors) organized in nests and the surrounding larval epidermal cells (LECs). An increasing stress gradient develops from the center of the nests toward the LECs as a result of the forces generated by histoblasts as they proliferate and by the LECs as they delaminate (push/pull coordination). This asymmetric radial coordination of expansive and contractile activities contributes to epithelial replacement. Our analyses support a model in which cell-cell mechanical communication is sufficient for the rearrangements that implement epithelial morphogenesis.
Identifiants
pubmed: 31858605
doi: 10.15252/embj.2019103594
pmc: PMC6996571
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e103594Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades (Ministry of Science, Innovation and Universities)
ID : BFU2014-57019-P
Pays : International
Organisme : Ministerio de Ciencia, Innovación y Universidades (Ministry of Science, Innovation and Universities)
ID : BFU2017-82876-P
Pays : International
Organisme : Ministerio de Ciencia, Innovación y Universidades (Ministry of Science, Innovation and Universities)
ID : BFU2010-21847-C02-01/BMC
Pays : International
Organisme : Fundación Ramón Areces (Ramón Areces Foundation)
Pays : International
Informations de copyright
© 2019 The Authors.
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