Study of pharmacist intervention in polypharmacy among older patients: Non-randomized, controlled trial.


Journal

Geriatrics & gerontology international
ISSN: 1447-0594
Titre abrégé: Geriatr Gerontol Int
Pays: Japan
ID NLM: 101135738

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 21 04 2019
revised: 15 11 2019
accepted: 27 11 2019
pubmed: 21 12 2019
medline: 2 6 2020
entrez: 21 12 2019
Statut: ppublish

Résumé

We investigated the outcomes of interdisciplinary drug therapy interventions by pharmacists among older residents of special elderly nursing homes. The study was designed as a non-randomized, parallel-group, controlled study. Four nursing homes were allocated in a 1:1 ratio to an intervention group (IG) or control group (CG). The participants of the study were residents taking five or more medications. The nursing homes in the IG were each visited by one pharmacist, who was charged with looking for potential problems in drug therapy. Activities in the CG were carried out as usual. The intervention period was 6 months. The primary end-points were the incidences of potentially inappropriate medication (PIM) and falls. The mean difference and proportion of participants were compared between groups. Data from 28 participants in the IG and 27 participants in the CG were analyzed. The number of PIM decreased from 2.64 at baseline to 2.39 after 6 months in the IG (P = 0.032). The proportion of participants in whom the use of PIM was reduced without problems was 17.9% in the IG and 3.7% in the CG (P = 0.094). The mean number of falls was 0.04 in the IG and 0.41 in the CG (P = 0.033). Falls occurred in 3.6% of participants in the IG and 22.2% of participants in the CG (P = 0.043). The results suggested a trend toward fewer PIM and falls in the IG. Geriatr Gerontol Int 2019; ••: ••-••.

Identifiants

pubmed: 31858696
doi: 10.1111/ggi.13850
doi:

Types de publication

Controlled Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

229-237

Subventions

Organisme : Japan Agency for Medical Research and Development

Informations de copyright

© 2019 Japan Geriatrics Society.

Références

Ministry of Health, Labor and Welfare, Results of “Survey of Long-term Care Benefit Expenditures” for 2011, Current status of recipients of nursing care services (Table 2-2(on Page 4)). [Cited 12 Mar 2018]. Available from URL: https://www.mhlw.go.jp/toukei/saikin/hw/kaigo/kyufu/11/dl/11.pdf
Ministry of Health, Labor and Welfare, Results of “Survey of Long-term Care Benefit Expenditures” for 2016, Current status of recipients of nursing care services (Table 2-2(on Page 4)). [Cited 12 Mar 2018]. Available from URL: https://www.mhlw.go.jp/toukei/saikin/hw/kaigo/kyufu/16/dl/11.pdf
Ministry of Health, Labor and Welfare, The 143rd Social Security Council Nursing Care Benefit Expense Subcommittee Material, Document No. 2 “Nursing Care Elderly Welfare Facility. [Cited 12 Mar 2018]. Available from URL: https://www.mhlw.go.jp/file/05-Shingikai-12601000-Seisakutoukatsukan-Sanjikanshitsu_Shakaihoshoutantou/0000171814.pdf
Japan Pharmaceutical Association. “Chiiki yakkyoku ni yoru zaitaku fukuyaku shien (zaitaku iryo kyotaku ryoyo) ni okeru yakubutsu ryoho no kojo oyobi koritsu-ka no tame no chosa kenkyu hokoku-sho, Chapter 2.”; 2010[Cited 29 Mar 2017]. Available from URL: http://www.nichiyaku.or.jp/action/wp-content/uploads/2010/08/21zaitaku_sien2.pdf
Nanaumi Y, Matoba S, Onda M et al. A pilot study into the attribute of patients who use Pharmacist's home-visiting and factors related to adherence among patients taking medication for dementia. Yakugaku Zasshi 2012; 132: 387-393. https://doi.org/10.1248/yakushi.132.387.
Kojima T, Akishita M, Kameyama Y et al. High risk of adverse drug reactions in elderly patients taking six or more drugs: analysis of inpatient database. Geriatr Gerontol Int 2012; 12: 761-762. https://doi.org/10.1111/j.1447-0594.2012.00868.x.
Frankenthal D, Lerman Y, Kalendaryev E, Lerman Y. Intervention with the screening tool of older persons potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria in elderly residents of a chronic geriatric facility: a randomized clinical trial. J Am Geriatr Soc 2014; 62: 1658-1665. https://doi.org/10.1111/jgs.12993.
Milos V, Rekman E, Bondesson Å et al. Improving the quality of pharmacotherapy in elderly primary care patients through medication reviews: a randomised controlled study. Drugs Aging 2013; 30: 235-246. https://doi.org/10.1007/s40266-013-0057-0.
Gallagher P, Ryan C, Byrne S, Kennedy J, O'Mahony D. STOPP (screening tool of older person's prescriptions) and START (screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharmacol Ther 2008; 46: 72-83.
American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012; 60: 616-631. https://doi.org/10.1111/j.1532-5415.2012.03923.x. Epub 2012 Feb 29. review.
Lam MP, Cheung BM. The use of STOPP/START criteria as a screening tool for assessing the appropriateness of medications in the elderly population. Expert Rev Clin Pharmacol 2012; 5: 187-197. https://doi.org/10.1586/ecp.12.6.
Anrys P, Strauven G, Boland B et al. Collaborative approach to optimise MEdication use for older people in nursing homes (COME-ON): study protocol of a cluster controlled trial. Implement Sci 2016; 11: 35. https://doi.org/10.1186/s13012-016-0394-6.
Wouters H, Quik EH, Boersma F et al. Discontinuing inappropriate medication in nursing home residents (DIM-NHR study): protocol of a cluster randomised controlled trial. BMJ Open 2014; 4: e006082. https://doi.org/10.1136/bmjopen-2014-006082.
Smeets CH, Smalbrugge M, Gerritsen DL et al. Improving psychotropic drug prescription in nursing home patients with dementia: design of a cluster randomized controlled trial. BMC Psychiatry 2013; 13: 280. https://doi.org/10.1186/1471-244X-13-280.
Mestres GC, de Wit HA, van Oijen BP et al. Supporting clinical rules engine in the adjustment of medication (SCREAM): protocol of a multicentre, prospective, randomised study. BMC Geriatr 2017; 17: 35. https://doi.org/10.1186/s12877-017-0426-3.
Nazir A, Unroe K, Tegeler M, Khan B, Azar J, Boustani M. Systematic review of interdisciplinary interventions in nursing homes. J Am Med Dir Assoc 2013; 14: 471-478. https://doi.org/10.1016/j.jamda.2013.02.005. Epub 2013 Apr 6.
Kojima T, Mizukami K, Tomita N et al. Screening tool for older persons’ appropriate prescriptions for Japanese: report of the Japan geriatrics society working group on “guidelines for medical treatment and its safety in the elderly”. Geriatr Gerontol Int 2016; 16: 983-1001. https://doi.org/10.1111/ggi.1289.
Schmader KE, Hanlon JT, Pieper CF et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med 2004; 116: 394-401. https://doi.org/10.1016/j.amjmed.2003.10.031.
Hashimoto R, Fujii K, Yoshida K et al. Outcomes of pharmacists’ involvement with residents of special nursing homes for the elderly. Yakugaku Zasshi 2018; 138: 1217-1225. https://doi.org/10.1248/yakushi.18-00065.
Ottenbacher KJ, Hsu Y, Granger CV, Fiedler RC. The reliability of the functional independence measure: a quantitative review. Arch Phys Med Rehabil 1996; 77: 1226-1232.
Yamamoto Y, Tanaka H, Takase M, Yamazaki M, Azumi K, Shirakawa S. Standardization of revised version of OSA sleep inventory for middle aged and aged. Brain Sci Mental Disorders 1999; 10: 401-409.
The Japan Geriatrics Society, Tokuni shinchōna tōyo o yōsuru yakubutsu no risuto’ ni gaitō suru yakuzai no ippan-mei to iyakuhin kōdo ichiran. List of generic names and pharmaceutical codes of drugs in the “List of drugs that should be used with particular caution.” 2017 [Cited 12 Mar 2018]. Available from URL: https://www.jpn-geriat-soc.or.jp/tool/xls/list_03.xlsx
Haumschild MJ, Karfonta TL, Haumschild MS, Phillips SE. Clinical and economic outcomes of a fall-focused pharmaceutical intervention program. Am J Health Syst Pharm 2003; 60: 1029-1032.
Berdot S, Bertrand M, Dartigues JF et al. Inappropriate medication use and risk of falls-a prospective study in a large community-dwelling elderly cohort. BMC Geriatr 2009; 9: 30. https://doi.org/10.1186/1471-2318-9-30.

Auteurs

Ryota Hashimoto (R)

Saera Pharmacy, Osaka, Japan.
Department of Social and Administrative Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan.

Keiko Fujii (K)

Saera Pharmacy, Osaka, Japan.

Shizuka Shimoji (S)

Saera Pharmacy, Osaka, Japan.

Atsuyuki Utsumi (A)

Well-seikokai, Osaka, Japan.

Kazutaka Hosokawa (K)

Well-seikokai, Osaka, Japan.

Hiroki Tochino (H)

Department of Social and Administrative Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan.

Shigeki Sanehisa (S)

Department of Social and Administrative Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan.

Masahiro Akishita (M)

Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Mitsuko Onda (M)

Department of Social and Administrative Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH