[Prognostic value of granular pattern of growth hormone secreting tumors].
Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico.
Journal
Revista medica de Chile
ISSN: 0717-6163
Titre abrégé: Rev Med Chil
Pays: Chile
ID NLM: 0404312
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
04
12
2018
accepted:
05
08
2019
entrez:
21
12
2019
pubmed:
21
12
2019
medline:
23
2
2020
Statut:
ppublish
Résumé
Classification of growth hormone (GH) - secreting tumors by the granular pattern might predict their clinical behavior in acromegalic patients. There are several other prognostic factors. To compare the features at presentation and cure rates of patients with GH secreting tumors according to the granular pattern, and to define independent prognostic factors for surgical treatment in these patients. A retrospective, observational study of 85 active acromegalic patients surgically treated in two medical centers. Seventy-four patients (87%) were classified as having densely granulated (DG) and 11 (13%) as sparsely granulated (SG) tumors. The latter were less active biochemically, had a higher rate of macroadenoma and cavernous sinus invasion and had a lower rate of biochemical cure than the DG group. Several characteristics were associated with disease persistence but only age (Odds ratio (OR) = 0.93) and cavernous sinus invasion (OR = 21.7) were independently associated in the logistic regression model. The sparsely granulated pattern is associated with a more aggressive behavior, but the main determinants of prognosis are age and cavernous sinus invasion.
Sections du résumé
BACKGROUND
BACKGROUND
Classification of growth hormone (GH) - secreting tumors by the granular pattern might predict their clinical behavior in acromegalic patients. There are several other prognostic factors.
AIM
OBJECTIVE
To compare the features at presentation and cure rates of patients with GH secreting tumors according to the granular pattern, and to define independent prognostic factors for surgical treatment in these patients.
MATERIAL AND METHODS
METHODS
A retrospective, observational study of 85 active acromegalic patients surgically treated in two medical centers.
RESULTS
RESULTS
Seventy-four patients (87%) were classified as having densely granulated (DG) and 11 (13%) as sparsely granulated (SG) tumors. The latter were less active biochemically, had a higher rate of macroadenoma and cavernous sinus invasion and had a lower rate of biochemical cure than the DG group. Several characteristics were associated with disease persistence but only age (Odds ratio (OR) = 0.93) and cavernous sinus invasion (OR = 21.7) were independently associated in the logistic regression model.
CONCLUSIONS
CONCLUSIONS
The sparsely granulated pattern is associated with a more aggressive behavior, but the main determinants of prognosis are age and cavernous sinus invasion.
Identifiants
pubmed: 31859983
pii: S0034-98872019000700852
doi: 10.4067/S0034-98872019000700852
pii:
doi:
Types de publication
Comparative Study
Journal Article
Observational Study
Langues
spa
Sous-ensembles de citation
IM