Proteolytic Queues at ClpXP Increase Antibiotic Tolerance.
Ampicillin
/ pharmacology
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ genetics
Ciprofloxacin
/ pharmacology
Drug Tolerance
/ physiology
Endopeptidase Clp
/ metabolism
Escherichia coli
/ drug effects
Escherichia coli Proteins
/ metabolism
Green Fluorescent Proteins
/ genetics
Plasmids
/ genetics
Proteolysis
/ drug effects
RNA-Binding Proteins
/ genetics
Sigma Factor
/ genetics
ClpXP
antibiotic resistance
antibiotic tolerance
persistence
protease
queueing
synthetic biology
Journal
ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075
Informations de publication
Date de publication:
17 01 2020
17 01 2020
Historique:
pubmed:
21
12
2019
medline:
26
1
2021
entrez:
21
12
2019
Statut:
ppublish
Résumé
Antibiotic tolerance is a widespread phenomenon that renders antibiotic treatments less effective and facilitates antibiotic resistance. Here we explore the role of proteases in antibiotic tolerance, short-term population survival of antibiotics, using queueing theory (
Identifiants
pubmed: 31860281
doi: 10.1021/acssynbio.9b00358
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Cyan Fluorescent Protein
0
Escherichia coli Proteins
0
RNA-Binding Proteins
0
Sigma Factor
0
sigma factor KatF protein, Bacteria
0
small protein B
0
Green Fluorescent Proteins
147336-22-9
Ciprofloxacin
5E8K9I0O4U
Ampicillin
7C782967RD
ClpXP protease, E coli
EC 3.4.21.92
Endopeptidase Clp
EC 3.4.21.92
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM