Network dynamics of Broca's area during word selection.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
12
2018
accepted:
12
11
2019
entrez:
21
12
2019
pubmed:
21
12
2019
medline:
26
3
2020
Statut:
epublish
Résumé
Current models of word-production in Broca's area (i.e. left ventro-lateral prefrontal cortex, VLPFC) posit that sequential and staggered semantic, lexical, phonological and articulatory processes precede articulation. Using millisecond-resolution intra-cranial recordings, we evaluated spatiotemporal dynamics and high frequency functional interconnectivity between left VLPFC regions during single-word production. Through the systematic variation of retrieval, selection, and phonological loads, we identified specific activation profiles and functional coupling patterns between these regions that fit within current psycholinguistic theories of word production. However, network interactions underpinning these processes activate in parallel (not sequentially), while the processes themselves are indexed by specific changes in network state. We found evidence that suggests that pars orbitalis is coupled with pars triangularis during lexical retrieval, while lexical selection is terminated via coupled activity with M1 at articulation onset. Taken together, this work reveals that speech production relies on very specific inter-regional couplings in rapid sequence in the language dominant hemisphere.
Identifiants
pubmed: 31860640
doi: 10.1371/journal.pone.0225756
pii: PONE-D-18-35949
pmc: PMC6924671
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0225756Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC014589
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS098981
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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