Pain Management in Patients with Multiple Myeloma: An Update.

bisphosphonate cancer survivors chemotherapy induced neuropathic pain denosumab multiple myeloma neuropathic pain opioids pain post-herpetic neuralgia skeletal-related events

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
17 Dec 2019
Historique:
received: 29 10 2019
revised: 10 12 2019
accepted: 12 12 2019
entrez: 22 12 2019
pubmed: 22 12 2019
medline: 22 12 2019
Statut: epublish

Résumé

Most patients with multiple myeloma (MM) suffer from chronic pain at every stage of the natural disease process. This review focuses on the most common causes of chronic pain in MM patients: (1) pain from myeloma bone disease (MBD); (2) chemotherapy-induced peripheral neuropathy as a possible consequence of proteasome inhibitor therapy (i.e., bortezomib-induced); (3) post-herpetic neuralgia as a possible complication of varicella zoster virus reactivation because of post-transplantation immunodepression; and (4) pain in cancer survivors, with increasing numbers due to the success of antiblastic treatments, which have significantly improved overall survival and quality of life. In this review, non-pain specialists will find an overview including a detailed description of physiopathological mechanisms underlying central sensitization and pain chronification in bone pain, the rationale for the correct use of analgesics and invasive techniques in different pain syndromes, and the most recent recommendations published on these topics. The ultimate target of this review was to underlie that different types of pain can be observed in MM patients, and highlight that only after an accurate pain assessment, clinical examination, and pain classification, can pain be safely and effectively addressed by selecting the right analgesic option for the right patient.

Identifiants

pubmed: 31861097
pii: cancers11122037
doi: 10.3390/cancers11122037
pmc: PMC6966684
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Flaminia Coluzzi (F)

Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy.

Roman Rolke (R)

Department of Palliative Medicine, Medical Faculty RWTH Aachen University, 52062 Aachen, Germany.

Sebastiano Mercadante (S)

Main regional center for Pain Relief & Supportive Care, La Maddalena Cancer Center, 90100 Palermo, Italy.

Classifications MeSH