Vascular Diseases and Gangliosides.
aging
atherosclerosis
ganglioside
inflammatory cells
senescence
vascular cells
vascular disease
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Dec 2019
17 Dec 2019
Historique:
received:
27
11
2019
revised:
12
12
2019
accepted:
16
12
2019
entrez:
22
12
2019
pubmed:
22
12
2019
medline:
6
5
2020
Statut:
epublish
Résumé
Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Risk factors for atherosclerosis include lifestyle and aging. It has been reported that lifespan could be extended in mice by targeting senescent cells, which led to the suppression of aging-related diseases, such as vascular diseases. However, the molecular mechanisms underlying the contribution of aging to vascular diseases are still not well understood. Several types of cells, such as vascular (endothelial cell), vascular-associated (smooth muscle cell and fibroblast) and inflammatory cells, are involved in plaque formation, plaque rupture and thrombus formation, which result in atherosclerosis. Gangliosides, a group of glycosphingolipids, are expressed on the surface of vascular, vascular-associated and inflammatory cells, where they play functional roles. Clarifying the role of gangliosides in atherosclerosis and their relationship with aging is fundamental to develop novel prevention and treatment methods for vascular diseases based on targeting gangliosides. In this review, we highlight the involvement and possible contribution of gangliosides to vascular diseases and further discuss their relationship with aging.
Identifiants
pubmed: 31861196
pii: ijms20246362
doi: 10.3390/ijms20246362
pmc: PMC6941100
pii:
doi:
Substances chimiques
Gangliosides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : JSPS KAKENHI
ID : 16K08263
Organisme : JSPS KAKENHI
ID : 19K11759
Organisme : JSPS KAKENHI
ID : 15H04715
Organisme : National Center for Child Health and Development
ID : no. 29-1
Organisme : Pancreas Research Foundation of Japan
ID : 2018
Organisme : Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
ID : 2018
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