Neurofibromatosis type 2 and multiple sclerosis.
Macrophages
Multiple sclerosis
Neurofibromatosis type 2
Schwannoma
T-cells
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
15
01
2019
revised:
27
10
2019
accepted:
08
12
2019
medline:
22
12
2019
pubmed:
22
12
2019
entrez:
22
12
2019
Statut:
ppublish
Résumé
Comorbidity of neurofibromatosis type 2 (NF2) and multiple sclerosis (MS) has rarely been reported. Since immunological mechanisms have been implicated in Nf2, coexistence of the two entities may offer insights into schwannoma pathogenesis with respect to the impact of the immune system. We present the case of a woman with a de novo mutation in the NF2 gene who later developed MS. In addition, we found a significantly higher count of T cells in a laryngeal schwannoma of this patient as compared to a schwannoma removed from a NF2 patient without MS. This finding correlated with a higher growth rate in the case of NF+MS.
Identifiants
pubmed: 31862656
pii: S2211-0348(19)30961-7
doi: 10.1016/j.msard.2019.101890
pii:
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
101890Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.