Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls.
Acute encephalitis
Diagnosis
Hematological disorders
Hematopoietic stem cell transplantation
Immunocompromised patients
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
08
07
2019
accepted:
10
11
2019
revised:
27
09
2019
pubmed:
22
12
2019
medline:
15
5
2021
entrez:
22
12
2019
Statut:
ppublish
Résumé
The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological disorders. Our data showed substantial heterogeneity in investigating patients. Not all patients had their CSF tested for viruses commonly responsible for encephalitis in immunocompetent individuals (e.g., VZV, enterovirus). A blood sample for the calculation of the CSF/blood replication ratio was collected in 74% of cases. CSF cultures and immunophenotyping of CSF cells were performed in 77% and 21% of patients, respectively. A multidisciplinary consensus is needed to improve current guidelines and standardize diagnostic protocols.
Identifiants
pubmed: 31863400
doi: 10.1007/s13365-019-00817-z
pii: 10.1007/s13365-019-00817-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM