Biodegradable zwitterionic polymer membrane coating endowing nanoparticles with ultra-long circulation and enhanced tumor photothermal therapy.

Erythrocyte Membrane Humans Nanoparticles Neoplasms / therapy Photothermal Therapy Polymers
Drug delivery Long circulation Photothermal therapy Protein adsorption Zwitterionic polymer membrane

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
02 2020
Historique:
received: 10 09 2019
revised: 10 12 2019
accepted: 11 12 2019
pubmed: 22 12 2019
medline: 15 5 2021
entrez: 22 12 2019
Statut: ppublish

Résumé

Long blood circulation is the basic requirement of advanced drug delivery systems for tumor treatment, which leads to enhanced tumor therapeutic efficiency and reduced side effects. However, the pharmacokinetics of the current nanoparticles in vivo is still unsatisfactory, which leads to limited success to translate nanoparticles into clinical applications. Inspired by the natural cell membrane-coating strategy, a series of zwitterionic polymer membranes are firstly developed and coated onto different kinds of nanoparticles in this work. Intriguingly, the zwitterionic polymer membrane shows stronger protein adsorption resistance and reduced macrophage uptake compared with the corresponding zwitterionic polymer brush or the red blood cell (RBC) membrane, which results in longer blood circulation time and higher tumor accumulation of the coated nanoparticles. Combined with the photothermal effect of model nanoparticles, Fe

Identifiants

DOI: 10.1016/j.biomaterials.2019.119680 PMID: 31864018
pubmed: 31864018
pii: S0142-9612(19)30779-3
doi: 10.1016/j.biomaterials.2019.119680
pii:
doi:

Substances chimiques

Polymers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

119680

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Shaojun Peng (S)

State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, PR China.

Boshu Ouyang (B)

The Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, PR China; Central Laboratory, First Affiliated Hospital, Dalian Medical University, Dalian, 116021, PR China.

Yongzhi Men (Y)

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China.

Yang Du (Y)

The Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, PR China; Central Laboratory, First Affiliated Hospital, Dalian Medical University, Dalian, 116021, PR China.

Yongbin Cao (Y)

State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, PR China.

Ruihong Xie (R)

State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, PR China.

Zhiqing Pang (Z)

Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, PR China. Electronic address: zqpang@fudan.edu.cn.

Shun Shen (S)

The Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, PR China. Electronic address: sshen@tongji.edu.cn.

Wuli Yang (W)

State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, PR China. Electronic address: wlyang@fudan.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Érythrocytes › Membrane érythrocytaire › Biodegradable zwitterionic polymer membrane...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biodegradable zwitterionic polymer membrane...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Biodegradable zwitterionic polymer membrane...
questionsmedicales.fr › Tumeurs › Biodegradable zwitterionic polymer membrane...
questionsmedicales.fr › Thérapeutique › Photothérapie › Thérapie photothermique › Biodegradable zwitterionic polymer membrane...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biodegradable zwitterionic polymer membrane...