Zona Incerta: An Integrative Node for Global Behavioral Modulation.
animal behavior
gain modulation
inhibitory nucleus
input/output pattern
motivation
neural plasticity
physiological state
processing node
subthalamic region
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
26
08
2019
revised:
14
11
2019
accepted:
19
11
2019
pubmed:
23
12
2019
medline:
19
8
2021
entrez:
23
12
2019
Statut:
ppublish
Résumé
Zona incerta (ZI) is a largely inhibitory subthalamic region connecting with many brain areas. Early studies have suggested involvement of ZI in various functions such as visceral activities, arousal, attention, and locomotion, but the specific roles of different ZI subdomains or cell types have not been well examined. Recent studies combining optogenetics, behavioral assays, neural tracing, and neural activity-recording reveal novel functional roles of ZI depending on specific input-output connectivity patterns. Here, we review these studies and summarize functions of ZI into four categories: sensory integration, behavioral output control, motivational drive, and neural plasticity. In view of these new findings, we propose that ZI serves as an integrative node for global modulation of behaviors and physiological states.
Identifiants
pubmed: 31864676
pii: S0166-2236(19)30220-6
doi: 10.1016/j.tins.2019.11.007
pmc: PMC7439563
mid: NIHMS1576316
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-87Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008983
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY019049
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025722
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH114112
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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