Virological response and retention in care according to time of starting ART in Italy: data from the Icona Foundation Study cohort.
Journal
The Journal of antimicrobial chemotherapy
ISSN: 1460-2091
Titre abrégé: J Antimicrob Chemother
Pays: England
ID NLM: 7513617
Informations de publication
Date de publication:
01 03 2020
01 03 2020
Historique:
received:
17
09
2019
revised:
07
11
2019
accepted:
11
11
2019
pubmed:
23
12
2019
medline:
25
6
2021
entrez:
23
12
2019
Statut:
ppublish
Résumé
To describe: (i) factors associated with rapid and delayed ART initiation; (ii) rates of 12 week virological response; and (iii) virologically controlled retention in care by 1 year from ART initiation according to timing of start in a real-life setting. All individuals in the Icona cohort diagnosed with HIV in 2016-17 who initiated ART were grouped according to the time between HIV diagnosis and ART initiation: Group 1, ≤7 days; Group 2, 8-14 days; Group 3, 15-30 days; Group 4, 31-120 days; and Group 5, >120 days. Multivariable logistic regression models were used to identify factors associated with: (i) the probability of rapid (Group 1) and very delayed (Group 5) ART initiation; (ii) the 12 week virological response (by a modified snapshot algorithm); and (iii) the probability of retention in care at 1 year (on ART with HIV-RNA <50 copies/mL). A total of 1247 individuals were included [82 (6.6%) in Group 1, 115 (9.2%) in Group 2, 267 (21.4%) in Group 3, 641 (51.4%) in Group 4 and 142 (11.4%) in Group 5]. Main predictors of rapid ART start (Group 1) were low CD4 cell count and high HIV-RNA at first contact with the infectious diseases centre. There was no association between probability of virological response and timing of ART initiation. Overall, 90% of individuals remained on ART after 1 year, 91% with undetectable HIV-RNA. Participants of Italian nationality, those with higher CD4 cell count and lower HIV-RNA at ART initiation were more likely to be retained in care after 1 year. In our high-income observational setting, we did not observe differences in the 1 year rate of virological response and retention in care according to timing of ART initiation.
Identifiants
pubmed: 31865395
pii: 5684822
doi: 10.1093/jac/dkz512
doi:
Substances chimiques
Anti-HIV Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
681-689Investigateurs
A d'Arminio Monforte
(A)
A Antinori
(A)
M Andreoni
(M)
A Castagna
(A)
F Castelli
(F)
R Cauda
(R)
G Di Perri
(G)
M Galli
(M)
R Iardino
(R)
G Ippolito
(G)
A Lazzarin
(A)
G C Marchetti
(GC)
G Rezza
(G)
F von Schloesser
(F)
P Viale
(P)
A d'Arminio Monforte
(A)
A Antinori
(A)
A Castagna
(A)
F Ceccherini-Silberstein
(F)
A Cozzi-Lepri
(A)
E Girardi
(E)
S Lo Caputo
(S)
C Mussini
(C)
M Puoti
(M)
C F Perno
(CF)
A Antinori
(A)
F Bai
(F)
C Balotta
(C)
A Bandera
(A)
S Bonora
(S)
M Borderi
(M)
A Calcagno
(A)
A Capetti
(A)
M R Capobianchi
(MR)
A Castagna
(A)
F Ceccherini-Silberstein
(F)
S Cicalini
(S)
A Cingolani
(A)
P Cinque
(P)
A Cozzi-Lepri
(A)
A d'Arminio Monforte
(A)
A De Luca
(A)
A Di Biagio
(A)
E Girardi
(E)
N Gianotti
(N)
A Gori
(A)
G Guaraldi
(G)
G Lapadula
(G)
M Lichtner
(M)
S Lo Caputo
(S)
G Madeddu
(G)
F Maggiolo
(F)
G Marchetti
(G)
L Monno
(L)
C Mussini
(C)
S Nozza
(S)
C F Perno
(CF)
C Pinnetti
(C)
M Puoti
(M)
E Quiros Roldan
(E)
R Rossotti
(R)
S Rusconi
(S)
M M Santoro
(MM)
A Saracino
(A)
L Sarmati
(L)
A Cozzi-Lepri
(A)
I Fanti
(I)
L Galli
(L)
P Lorenzini
(P)
A Rodano'
(A)
M Macchia
(M)
A Tavelli
(A)
F Carletti
(F)
S Carrara
(S)
A Di Caro
(A)
S Graziano
(S)
F Petroni
(F)
G Prota
(G)
S Truffa
(S)
A Giacometti
(A)
A Costantini
(A)
V Barocci
(V)
G Angarano
(G)
L Monno
(L)
E Milano
(E)
F Maggiolo
(F)
C Suardi
(C)
P Viale
(P)
V Donati
(V)
G Verucchi
(G)
F Castelnuovo
(F)
C Minardi
(C)
E Quiros Roldan
(E)
B Menzaghi
(B)
C Abeli
(C)
B Cacopardo
(B)
B Celesia
(B)
J Vecchiet
(J)
K Falasca
(K)
A Pan
(A)
S Lorenzotti
(S)
L Sighinolfi
(L)
D Segala
(D)
P Blanc
(P)
F Vichi
(F)
G Cassola
(G)
C Viscoli
(C)
A Alessandrini
(A)
N Bobbio
(N)
G Mazzarello
(G)
M Lichtner
(M)
L Fondaco
(L)
P Bonfanti
(P)
C Molteni
(C)
A Chiodera
(A)
P Milini
(P)
G Nunnari
(G)
G Pellicanò
(G)
A d'Arminio Monforte
(A)
M Galli
(M)
A Lazzarin
(A)
G Rizzardini
(G)
M Puoti
(M)
A Castagna
(A)
E S Cannizzo
(ES)
M C Moioli
(MC)
R Piolini
(R)
D Bernacchia
(D)
S Salpietro
(S)
C Tincati
(C)
C Mussini
(C)
C Puzzolante
(C)
C Migliorino
(C)
G Lapadula
(G)
V Sangiovanni
(V)
G Borgia
(G)
V Esposito
(V)
G Di Flumeri
(G)
I Gentile
(I)
V Rizzo
(V)
A M Cattelan
(AM)
S Marinello
(S)
A Cascio
(A)
M Trizzino
(M)
D Francisci
(D)
E Schiaroli
(E)
G Parruti
(G)
F Sozio
(F)
G Magnani
(G)
M A Ursitti
(MA)
M Andreoni
(M)
A Antinori
(A)
R Cauda
(R)
A Cristaudo
(A)
V Vullo
(V)
R Acinapura
(R)
D Moschese
(D)
M Capozzi
(M)
A Mondi
(A)
A Cingolani
(A)
M Rivano Capparuccia
(M)
G Iaiani
(G)
A Latini
(A)
R Gagliardini
(R)
M M Plazzi
(MM)
G De Girolamo
(G)
A Vergori
(A)
M Cecchetto
(M)
F Viviani
(F)
G Madeddu
(G)
A De Vito
(A)
B Rossetti
(B)
F Montagnani
(F)
A Franco
(A)
R Fontana Del Vecchio
(R)
C Di Giuli
(C)
P Caramello
(P)
G Di Perri
(G)
S Bonora
(S)
G C Orofino
(GC)
M Sciandra
(M)
M Bassetti
(M)
A Londero
(A)
V Manfrin
(V)
G Battagin
(G)
G Starnini
(G)
A Ialungo
(A)
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.