Anxiety risk SNPs on chromosome 2 modulate arousal in children in a fear generalization paradigm.
Anxiety disorders
Anxiety risk genes
Anxious personality traits
Arousal
Childhood and adolescence
Fear conditioning and generalization
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
22
09
2019
accepted:
11
12
2019
pubmed:
23
12
2019
medline:
21
10
2020
entrez:
23
12
2019
Statut:
ppublish
Résumé
Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult individuals. In this study, we evaluated findings of a recent meta-analysis of genome-wide association studies in adult anxiety disorders with significant associations of four single nucleotide polymorphisms (SNPs) in a large cohort of 347 healthy children (8-12 years) characterized for dimensional anxiety. We investigated the modulation of anxiety parameters by these SNPs in a discriminative fear conditioning and generalization paradigm in the to-date largest sample of children. Results extended findings of the meta-analysis showing a genomic locus on 2p21 to modulate anxious personality traits and arousal ratings. These SNPs might, thus, serve as susceptibility markers for a shared risk across pathological anxiety, presumably mediated by alterations in arousal.
Identifiants
pubmed: 31865460
doi: 10.1007/s00787-019-01458-7
pii: 10.1007/s00787-019-01458-7
pmc: PMC7497385
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1301-1310Subventions
Organisme : DFG
ID : SFB_TRR58
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