The prognostic and diagnostic use of hematological parameters in subacute thyroiditis patients.
Hypothyroidism
Mean platelet volume
Neutrophil-to-lymphocyte ratio
Platelet-to-lymphocyte ratio
Recurrence
Subacute thyroiditis
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
24
10
2019
accepted:
11
12
2019
pubmed:
23
12
2019
medline:
22
6
2021
entrez:
23
12
2019
Statut:
ppublish
Résumé
Subacute thyroiditis (SAT) is an acute inflammatory disease of the thyroid. Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) values determined from peripheral blood, are accepted as available and practical indicators of systemic inflammation. The purpose of this study was to evaluate the value of hematological parameters in the diagnosis and prognosis of subacute thyroiditis patients. This retrospective study included 306 SAT patients and 102 healthy control subjects. Retrospective analyses were made of age, gender, complete blood counts, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), thyroid function tests, NLR, PLR, and thyroid volume of the patients and the results were compared with the control group. The mean follow-up time of patients was 29.5 ± 14 months. The ESR, CRP, white blood cell (WBC) count, neutrophil count, hemoglobin, platelet counts, NLR, and PLR were significantly higher in the SAT patients. MPV and lymphocyte count were significantly lower in the SAT patients. The rates of recurrence and permanent hypothyroidism were 15.4% and 9.8%, respectively. The values of ESR, CRP, NLR, PLR, and MPV at the time of diagnosis were not determined to have any effect on recurrence or the development of permanent hypothyroidism. The results of this study showed higher PLR and NLR values in SAT patients compared with healthy control subjects, and a lower MPV value. These findings demonstrate that the assessment of hematological parameters in conjunction with radiological and clinical findings will assist in establishing an accurate diagnosis, especially in complicated SAT cases.
Sections du résumé
BACKGROUND
Subacute thyroiditis (SAT) is an acute inflammatory disease of the thyroid. Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) values determined from peripheral blood, are accepted as available and practical indicators of systemic inflammation. The purpose of this study was to evaluate the value of hematological parameters in the diagnosis and prognosis of subacute thyroiditis patients.
METHODS
This retrospective study included 306 SAT patients and 102 healthy control subjects. Retrospective analyses were made of age, gender, complete blood counts, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), thyroid function tests, NLR, PLR, and thyroid volume of the patients and the results were compared with the control group.
RESULTS
The mean follow-up time of patients was 29.5 ± 14 months. The ESR, CRP, white blood cell (WBC) count, neutrophil count, hemoglobin, platelet counts, NLR, and PLR were significantly higher in the SAT patients. MPV and lymphocyte count were significantly lower in the SAT patients. The rates of recurrence and permanent hypothyroidism were 15.4% and 9.8%, respectively. The values of ESR, CRP, NLR, PLR, and MPV at the time of diagnosis were not determined to have any effect on recurrence or the development of permanent hypothyroidism.
CONCLUSIONS
The results of this study showed higher PLR and NLR values in SAT patients compared with healthy control subjects, and a lower MPV value. These findings demonstrate that the assessment of hematological parameters in conjunction with radiological and clinical findings will assist in establishing an accurate diagnosis, especially in complicated SAT cases.
Identifiants
pubmed: 31865557
doi: 10.1007/s12020-019-02163-w
pii: 10.1007/s12020-019-02163-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
138-143Références
A.A. Alfadda, R.M. Sallam, G.E. Elawad, H. Aldhukair, M.M. Alyahya, Subacute thyroiditis: clinical presentation and long term outcome. Int. J. Endocrinol. 15, 743–794 (2014)
R. Olah, P. Hajos, Z. Soos, G. Winkler, De quervain thyroiditis. Corner points of the diagnosis. Orv. Hetil. 155, 676–680 (2014)
doi: 10.1556/OH.2014.29865
C. Cappelli, I. Pirola, E. Gandossi, A.M. Formenti, B. Agosti, M. Castellano, Ultrasound findings of subacute thyroiditis: a single institution retrospective review. Acta Radiol. 55(4), 429–433 (2014)
doi: 10.1177/0284185113498721
M. Stojkovic Lalosevic, A. Pavlovic Markovic, S. Stankovic et al. Combined diagnostic efficacy of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and Mean Platelet Volume (MPV) as biomarkers of systemic inflammation in the diagnosis of colorectal cancer. Dis. Markers 2019, 6036979 (2019). https://www.hindawi.com/journals/dm/2019/6036979/ . Assessed 21 Jul 2019
A. Yavuzcan, M. Çağlar, Y. Üstün et al. Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma. J. Turk. Ger. Gynecol. Assoc. 14(4), 210–215 (2013)
doi: 10.5152/jtgga.2013.55452
A.Y. Gasparyan, A. Sandoo, A. Stavropoulos-Kalinoglou, G.D. Kitas, Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-α therapy. Rheumatol. Int. 30(8), 1125–1129 (2010)
doi: 10.1007/s00296-009-1345-1
A.Y. Gasparyan, A. Sandoo, A. Stavropoulos-Kalinoglou, G.D. Kitas, “Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-α therapy,” Rheumatol. Int. 30(8), 1125–1129 (2010)
doi: 10.1007/s00296-009-1345-1
F. Imtiaz, K. Shafique, S.S. Mirza, Z. Ayoob, P. Vart, S. Rao, Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch. Med. 5(1), 2 (2012)
doi: 10.1186/1755-7682-5-2
G. Aktas, M. Sit, O. Dikbas et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis. Rev. Assoc. Med. Bras. (1992). 63(12), 1065–1068 (2017)
doi: 10.1590/1806-9282.63.12.1065
O. Yüksel, K. Helvaci, O. Başar et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets 20(4), 277–281 (2009)
doi: 10.1080/09537100902856781
A.Y. Gasparyan, L. Ayvazyan, U. Mukanova, M. Yessirkepov, G.D. Kitas, The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann. Lab Med. 39(4), 345–357 (2019)
doi: 10.3343/alm.2019.39.4.345
F. Kilinc, Y. Ergun, Z. Pekkolay et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of subacute thyroiditis. Prog. Nutr. 20(3), 510–515 (2018)
N. Kalay, O. Dogdu, F. Koc et al. Hematologic parameters and angiographic progression of coronary atherosclerosis. Angiology 63(3), 213–217 (2012)
doi: 10.1177/0003319711412763
H. Shimada, N. Takiguchi, O. Kainuma et al. High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer 13(3), 170–176 (2010)
doi: 10.1007/s10120-010-0554-3
S.C.H. Kao, N. Pavlakis, R. Harvie et al. High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy. Clin. Cancer Res J. Am. Assoc. Cancer Res 16(23), 5805–5813 (2010)
doi: 10.1158/1078-0432.CCR-10-2245
Y. Ohno, J. Nakashima, M. Ohori, T. Hatano, M. Tachibana, Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma. J. Urol. 184(3), 873–878 (2010)
doi: 10.1016/j.juro.2010.05.028
A. Panasiuk, “Płytki krwi w przewlekłych chorobach wątroby,” Med. Sci. Rev. Hepatologia 11, 83–86 (2011)
doi: 10.5604/17305039.970953
K. Kaushansky, The molecular mechanisms that control thrombopoiesis. J. Clin. Investig. 115(12), 3339–3347 (2005)
doi: 10.1172/JCI26674
A. Korniluk, O.M. Koper-Lenkiewicz, J. Kamińska, H. Kemona, V. Dymicka-Piekarska, Mean Platelet Volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 9213074 (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501263/ . Accessed 9 Sep 2019
N. Li, Z. Yu, X. Zhang et al. Elevated mean platelet volume predicts poor prognosis in colorectal cancer. Sci. Rep. 7(1), 10261 (2017)
doi: 10.1038/s41598-017-11053-y
X. Gong, L. Zhang, D. Yang et al. Mean platelet volume/platelet count ratio is associated with prognosis in patients with pancreatic cancer. Int. J. Clin. Exp. Med. 9(8), 16379–16386 (2016)
X.-M. Shen, Y.-Y. Xia, L. Lian et al. Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer. Oncol. Lett. 12(4), 2501–2506 (2016)
doi: 10.3892/ol.2016.4913
S. Kumagai, J. Tokuno, Y. Ueda et al. Prognostic significance of preoperative mean platelet volume in resected non-small-cell lung cancer. Mol. Clin. Oncol. 3(1), 197–201 (2015)
doi: 10.3892/mco.2014.436
A. Carlioglu, O. Timur, S.A. Durmaz, M.E. Ayhan, Mean platelet volume in euthyroid patients with Hashimoto’s thyroiditis. Blood Coagul. Fibrinolysis Int J. Haemost. Thromb. 26(3), 282–284 (2015)
doi: 10.1097/MBC.0000000000000236
S.M. Kim, E.H. Kim, B.H. Kim et al. Association of the preoperative neutrophil-to-ymphocyte count ratio and platelet-to-lymphocyte count ratio with clinicopathological characteristics in patients with papillary thyroid cancer. Endocrinol. Metab. Seoul. Korea 30(4), 494–501 (2015)
doi: 10.3803/EnM.2015.30.4.494
M. Bilge, A. Yesilova, M. Adas, A. Helvaci, Neutrophil- and platelet- to lymphocyte ratio in patients with euthyroid hashimoto’s thyroiditis. Exp. Clin. Endocrinol. Diabetes J. Ger. Soc. Endocrinol. Ger. Diabetes Assoc. 127(8), 545–549 (2018)
M.F. Pascutti, M.N. Erkelens, M.A. Nolte, Impact of viral infections on hematopoiesis: from beneficial to detrimental effects on bone marrow output. Front Immunol. 7, 364 (2016). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025449/ . Accessed 9 Sep 2019
S.P. Thomson, L.J. McMahon, C.A. Nugent, Endogenous cortisol: a regulator of the number of lymphocytes in peripheral blood. Clin. Immunol. Immunopathol. 17(4), 506–514 (1980)
doi: 10.1016/0090-1229(80)90146-4
V. Fatourechi, J.P. Aniszewski, G.Z.E. Fatourechi, E.J. Atkinson, S.J. Jacobsen, Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study. J. Clin. Endocrinol. Metab. 88(5), 2100–2105 (2003)
doi: 10.1210/jc.2002-021799
T. Mizukoshi, S. Noguchi, T. Murakami, T. Futata, H. Yamashita, Evaluation of recurrence in 36 subacute thyroiditis patients managed with prednisolone. Intern Med Tokyo Jpn 40(4), 292–295 (2001)
doi: 10.2169/internalmedicine.40.292
M. Stasiak, B. Tymoniuk, B. Stasiak, A. Lewiński, The risk of recurrence of subacute thyroiditis is hla-dependent. Int J. Mol. Sci. 20(5), E1089 (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429176/ . Accessed 9 Sep 2019
C.A. Benbassat, D. Olchovsky, G. Tsvetov, I. Shimon, Subacute thyroiditis: clinical characteristics and treatment outcome in fifty-six consecutive patients diagnosed between 1999 and 2005. J. Endocrinol. Investig. 30(8), 631–635 (2007)
doi: 10.1007/BF03347442