Influence of Genetic Variation in

Adolescent Adult Brain Ischemia / etiology Child Cyclic Nucleotide Phosphodiesterases, Type 3 / genetics Endothelium, Vascular / physiopathology Female Follow-Up Studies Genetic Predisposition to Disease Genetic Variation Humans Hypertension / complications Male Middle Aged Polymorphism, Single Nucleotide Pregnancy Pregnancy Complications, Cardiovascular / genetics Retrospective Studies Risk Factors Vasodilation / physiology Young Adult
cyclic nucleotide phosphodiesterases, type 3 genetics genome-wide association study stroke vascular endothelium

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
02 2020
Historique:
pubmed: 24 12 2019
medline: 22 10 2020
entrez: 24 12 2019
Statut: ppublish

Résumé

We aimed to characterize the genetics of endothelial function and how this influences risk for cardiovascular diseases such as ischemic stroke. We integrated genetic data from a study of ultrasound flow-mediated dilatation of brachial artery in adolescents from ALSPAC (Avon Longitudinal Study of Parents and Children; n=5214) with a study of ischemic stroke (MEGASTROKE: n=60 341 cases and 452 969 controls) to identify variants that confer risk of ischemic stroke through altered endothelial function. We identified a variant in

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.119.13513 PMID: 31865795 PMC: PMC7055937
pubmed: 31865795
doi: 10.1161/HYPERTENSIONAHA.119.13513
pmc: PMC7055937
doi:

Substances chimiques

Cyclic Nucleotide Phosphodiesterases, Type 3 EC 3.1.4.17
PDE3A protein, human EC 3.1.4.17

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

365-371

Subventions

Organisme : Medical Research Council
ID : MC_EX_MR/M009203/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9521010
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009203/1
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS103924
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/16/4/32218
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : K23 NS086873
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_14089
Pays : United Kingdom
Organisme : Medical Research Council
ID : 102215/2/13/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom

Références

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Auteurs

Matthew Traylor (M)

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., A.A.A.O., H.S.M.).
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.T.).

Ali Amin Al Olama (A)

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., A.A.A.O., H.S.M.).

Leo-Pekka Lyytikäinen (LP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).
Department of Clinical Chemistry (L.-P.L., T.L.), Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Finland.

Sandro Marini (S)

Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M., J.C., C.D.A.).
Division of Neurocritical Care and Emergency Neurology, Department of Neurology (S.M., C.D.A.), Massachusetts General Hospital, Boston.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S.M., J.C., C.D.A.).

Jaeyoon Chung (J)

Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M., J.C., C.D.A.).
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S.M., J.C., C.D.A.).

Rainer Malik (R)

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany (R.M., M.D.).

Martin Dichgans (M)

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany (R.M., M.D.).
Munich Cluster for Systems Neurology, Germany (M.D.).

Mika Kähönen (M)

Department of Clinical Physiology (M.K.), Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Finland.
Department of Clinical Physiology, Tampere University Hospital, Finland (M.K.).

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).
Department of Clinical Chemistry (L.-P.L., T.L.), Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Finland.

Christopher D Anderson (CD)

Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M., J.C., C.D.A.).
Division of Neurocritical Care and Emergency Neurology, Department of Neurology (S.M., C.D.A.), Massachusetts General Hospital, Boston.
Department of Neurology, McCance Center for Brain Health (C.D.A.), Massachusetts General Hospital, Boston.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S.M., J.C., C.D.A.).

Olli T Raitakari (OT)

Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.).
Research Centre of Applied and Preventative Cardiovascular Medicine, University of Turku, Finland (O.T.R.).

Hugh S Markus (HS)

From the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., A.A.A.O., H.S.M.).

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Influence of Genetic Variation in
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Influence of Genetic Variation in
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › Influence of Genetic Variation in
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Influence of Genetic Variation in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › 3',5'-Cyclic-AMP Phosphodiesterases › Cyclic Nucleotide Phosphodiesterases, Type 3 › Influence of Genetic Variation in
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Influence of Genetic Variation in
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Influence of Genetic Variation in
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Influence of Genetic Variation in
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Influence of Genetic Variation in
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Influence of Genetic Variation in
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Influence of Genetic Variation in
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Influence of Genetic Variation in
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Influence of Genetic Variation in
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Influence of Genetic Variation in
questionsmedicales.fr › Maladies cardiovasculaires › Complications cardiovasculaires de la grossesse › Influence of Genetic Variation in
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Influence of Genetic Variation in
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Influence of Genetic Variation in
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Influence of Genetic Variation in
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Influence of Genetic Variation in