Ambient Air Pollution and Mortality After Cardiac Transplantation.
ambient air pollution
heart failure
heart transplantation
mortality
particulate matter
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
17 12 2019
17 12 2019
Historique:
received:
26
03
2019
revised:
26
09
2019
accepted:
30
09
2019
entrez:
24
12
2019
pubmed:
24
12
2019
medline:
23
5
2020
Statut:
ppublish
Résumé
Heart transplant recipients are at high risk for mortality, with traditional risk scores performing modestly in predicting post-transplant survival, underscoring the importance of as yet unidentified factors in determining prognosis. In this analysis, the association between PM This study sought to study the association between PM On the basis of the zip code of residence, mortality data in patients who underwent heart transplantation (2004 to 2015) in the United Network for Organ Sharing (UNOS) database were linked with validated estimates of fine particulate matter concentrations (particles with diameter <2.5 μm [PM A total of 21,800 patients with 86,713 patient-years of follow-up was included. Mean age at transplantation was 52.6 ± 12.6 years, 75% were male, 69% were white, and 39% had ischemic etiology of heart failure. Mean annual exposure to PM This study provides evidence linking air pollution with mortality after heart transplantation. These results suggest an important influence of a key environmental factor in outcomes following heart transplantation, and supports the need for further studies in this population.
Sections du résumé
BACKGROUND
Heart transplant recipients are at high risk for mortality, with traditional risk scores performing modestly in predicting post-transplant survival, underscoring the importance of as yet unidentified factors in determining prognosis. In this analysis, the association between PM
OBJECTIVES
This study sought to study the association between PM
METHODS
On the basis of the zip code of residence, mortality data in patients who underwent heart transplantation (2004 to 2015) in the United Network for Organ Sharing (UNOS) database were linked with validated estimates of fine particulate matter concentrations (particles with diameter <2.5 μm [PM
RESULTS
A total of 21,800 patients with 86,713 patient-years of follow-up was included. Mean age at transplantation was 52.6 ± 12.6 years, 75% were male, 69% were white, and 39% had ischemic etiology of heart failure. Mean annual exposure to PM
CONCLUSIONS
This study provides evidence linking air pollution with mortality after heart transplantation. These results suggest an important influence of a key environmental factor in outcomes following heart transplantation, and supports the need for further studies in this population.
Identifiants
pubmed: 31865970
pii: S0735-1097(19)38022-2
doi: 10.1016/j.jacc.2019.09.066
pii:
doi:
Substances chimiques
Particulate Matter
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3026-3035Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES019616
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB026291
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.