Human Cytomegalovirus miRNAs Regulate TGF-β to Mediate Myelosuppression while Maintaining Viral Latency in CD34
Antigens, CD34
/ metabolism
Cells, Cultured
Cytomegalovirus
/ genetics
Cytomegalovirus Infections
/ metabolism
Down-Regulation
HEK293 Cells
Hematopoietic Stem Cells
/ metabolism
Host-Pathogen Interactions
Humans
MicroRNAs
/ metabolism
Myeloid Cells
/ metabolism
Repressor Proteins
/ metabolism
Signal Transduction
Smad3 Protein
/ metabolism
Transforming Growth Factor beta
/ metabolism
Virus Activation
Virus Latency
/ genetics
CD34(+) hematopoietic progenitor cells
NAB1
SMAD3
TGF-β
hematopoiesis
human cytomegalovirus
latency
miRNAs
myelosuppression
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
08 01 2020
08 01 2020
Historique:
received:
12
08
2019
revised:
25
10
2019
accepted:
22
11
2019
pubmed:
24
12
2019
medline:
15
5
2020
entrez:
24
12
2019
Statut:
ppublish
Résumé
Infection with human cytomegalovirus (HCMV) remains a significant cause of morbidity and mortality following hematopoietic stem cell transplant (HSCT) because of various hematologic problems, including myelosuppression. Here, we demonstrate that latently expressed HCMV miR-US5-2 downregulates the transcriptional repressor NGFI-A binding protein (NAB1) to induce myelosuppression of uninfected CD34
Identifiants
pubmed: 31866424
pii: S1931-3128(19)30595-5
doi: 10.1016/j.chom.2019.11.013
pmc: PMC6952548
mid: NIHMS1545144
pii:
doi:
Substances chimiques
Antigens, CD34
0
MicroRNAs
0
NAB1 protein, human
0
Repressor Proteins
0
SMAD3 protein, human
0
Smad3 Protein
0
Transforming Growth Factor beta
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-114.e4Subventions
Organisme : NIAID NIH HHS
ID : P01 AI127335
Pays : United States
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM134974
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI056077
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120619
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI021640
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI021640
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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