Role of cholesterol-mediated effects in GPCR heterodimers.
Adenosine(2A) receptor
Cholesterol
Dopamine D(3) receptor
G protein-coupled receptors
Heterodimer
MARTINI coarse-grain simulation
Journal
Chemistry and physics of lipids
ISSN: 1873-2941
Titre abrégé: Chem Phys Lipids
Pays: Ireland
ID NLM: 0067206
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
29
07
2019
revised:
16
12
2019
accepted:
16
12
2019
pubmed:
24
12
2019
medline:
27
3
2021
entrez:
24
12
2019
Statut:
ppublish
Résumé
G protein-coupled receptors (GPCRs) are transmembrane receptors that mediate a large number of cellular responses. The organization of GPCRs into dimers and higher-order oligomers is known to allow a larger repertoire of downstream signaling events. In this context, a crosstalk between the adenosine and dopamine receptors has been reported, indicating the presence of heterodimers that are functionally relevant. In this paper, we explored the effect of membrane cholesterol on the adenosine
Identifiants
pubmed: 31866438
pii: S0009-3084(19)30282-8
doi: 10.1016/j.chemphyslip.2019.104852
pii:
doi:
Substances chimiques
Lipid Bilayers
0
Receptors, Adenosine A2
0
Receptors, Dopamine D3
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104852Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.