A Perspective on the Role of Dynamic Alternative RNA Splicing in the Development, Specification, and Function of Axon Initial Segment.

Rbfox alternative splicing ankyrin axon initial segment homeostatic plasticity neurofascin neuronal activity spectrin

Journal

Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914

Informations de publication

Date de publication:
2019
Historique:
received: 20 09 2019
accepted: 15 11 2019
entrez: 24 12 2019
pubmed: 24 12 2019
medline: 24 12 2019
Statut: epublish

Résumé

Alternative splicing is a powerful mechanism for molecular and functional diversification. In neurons, alternative splicing extensively controls various developmental steps as well as the plasticity and remodeling of neuronal activity in the adult brain. The axon initial segment (AIS) is the specialized compartment of proximal axons that initiates action potential (AP). At the AIS, the ion channels and cell adhesion molecules (CAMs) required for AP initiation are densely clustered

Identifiants

pubmed: 31866821
doi: 10.3389/fnmol.2019.00295
pmc: PMC6906172
doi:

Types de publication

Journal Article

Langues

eng

Pagination

295

Informations de copyright

Copyright © 2019 Iijima and Yoshimura.

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Auteurs

Takatoshi Iijima (T)

Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan.

Takeshi Yoshimura (T)

Department of Child Development and Molecular Brain Science, United Graduate School of Child Development, Osaka University, Suita, Japan.

Classifications MeSH