Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis.
ERK
GLI1
Hedgehog signaling
cutaneous squamous cell carcinoma
epidermal growth factor receptor
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
03
2019
accepted:
25
10
2019
entrez:
24
12
2019
pubmed:
24
12
2019
medline:
24
12
2019
Statut:
epublish
Résumé
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor in humans. Although current therapies are sufficient to clear the tumor in many cases, the overall risk of cSCC metastasis is still 5%. Alternative treatment options could help to overcome this situation. Here we focused on the role of the Hedgehog (HH) signaling pathway and its interplay with epidermal growth factor receptor (EGFR) signaling in cSCC. The analyses revealed that, despite lack of Sonic HH (SHH) expression, a subset of human cSCC can express
Identifiants
pubmed: 31867038
doi: 10.3389/fgene.2019.01185
pmc: PMC6904360
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1185Informations de copyright
Copyright © 2019 Pyczek, Khizanishvili, Kuzyakova, Zabel, Bauer, Nitzki, Emmert, Schön, Boukamp, Schildhaus, Uhmann and Hahn.
Références
Oncogene. 2013 Aug 29;32(35):4181-8
pubmed: 23045271
PLoS One. 2011;6(12):e29159
pubmed: 22195012
EMBO Mol Med. 2012 Mar;4(3):218-33
pubmed: 22294553
Sci Rep. 2016 Apr 25;6:24928
pubmed: 27109116
Mol Cancer Ther. 2011 Nov;10(11):2179-88
pubmed: 21878656
PLoS One. 2013;8(1):e54355
pubmed: 23349860
J Invest Dermatol. 2013 May;133(5):1311-20
pubmed: 23223138
Cancer Res. 2013 Jun 1;73(11):3381-92
pubmed: 23576557
Open Access Maced J Med Sci. 2017 Dec 31;6(1):152-155
pubmed: 29484016
Front Oncol. 2015 Jun 08;5:130
pubmed: 26106586
Br J Dermatol. 2017 May;176(5):1279-1287
pubmed: 27510450
Vitam Horm. 2012;88:25-54
pubmed: 22391298
Cancer Res. 2005 May 1;65(9):3958-65
pubmed: 15867397
JAMA Dermatol. 2016 May 1;152(5):527-32
pubmed: 26914338
Nat Rev Cancer. 2008 Oct;8(10):743-54
pubmed: 18813320
Oncogenesis. 2018 Feb 20;7(2):17
pubmed: 29463844
J Cell Biol. 1982 Apr;93(1):1-4
pubmed: 7040412
Anticancer Res. 2005 Mar-Apr;25(2B):1205-10
pubmed: 15865067
Curr Biol. 2005 Aug 9;15(15):1340-51
pubmed: 16085486
Oncogene. 2011 Feb 10;30(6):714-23
pubmed: 20972463
Dis Markers. 2016;2016:4517492
pubmed: 27642215
Head Neck. 2011 Feb;33(2):244-50
pubmed: 20848446
J Invest Dermatol. 2000 Dec;115(6):1095-103
pubmed: 11121147
Head Neck. 2011 Feb;33(2):189-98
pubmed: 20848439
Cancer Sci. 2012 Dec;103(12):2120-6
pubmed: 22974223
Dermatology. 2001;202(3):203-6
pubmed: 11385224
Hautarzt. 2016 Nov;67(11):857-866
pubmed: 27680009
J Natl Cancer Inst. 1982 Mar;68(3):415-27
pubmed: 6950169
FEBS Lett. 2006 Mar 20;580(7):1859-64
pubmed: 16516204
Nature. 2007 Feb 15;445(7129):761-5
pubmed: 17230190
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2973-8
pubmed: 17299056
Br J Dermatol. 2007 Jan;156(1):92-8
pubmed: 17199573
Otolaryngol Head Neck Surg. 2016 Aug;155(2):281-8
pubmed: 27095050
J Dermatol. 2018 Oct;45(10):1181-1186
pubmed: 30035333
Nature. 2003 Oct 23;425(6960):851-6
pubmed: 14520413
Mol Carcinog. 2009 May;48(5):408-19
pubmed: 18781608
Cancer Res. 2009 Feb 15;69(4):1284-92
pubmed: 19190345
Cancer Lett. 2013 Sep 10;338(1):82-8
pubmed: 22579650
Traffic. 2014 Jun;15(6):648-64
pubmed: 24921075
Biosci Trends. 2007 Dec;1(3):156-60
pubmed: 20103886
Tumour Biol. 2016 Oct 17;:null
pubmed: 27752995
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Clin Exp Metastasis. 2011 Jun;28(5):437-49
pubmed: 21442356
Clin Cancer Res. 2014 Dec 15;20(24):6582-92
pubmed: 25303977
Expert Rev Mol Med. 2015 Feb 09;17:e5
pubmed: 25660620
In Vitro Cell Dev Biol. 1988 Aug;24(8):764-70
pubmed: 2457573
N Engl J Med. 2015 Sep 10;373(11):1079-82
pubmed: 26352826
J Invest Dermatol. 2001 Apr;116(4):614-6
pubmed: 11286632
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6
pubmed: 12391318
Dermatology. 2016;232(6):721-730
pubmed: 28384639
Nat Rev Mol Cell Biol. 2005 Apr;6(4):306-17
pubmed: 15803137
Nat Struct Mol Biol. 2010 Jun;17(6):718-25
pubmed: 20512148
J Clin Invest. 2012 Feb;122(2):464-72
pubmed: 22293185
Br J Dermatol. 2014 Nov;171(5):1014-21
pubmed: 24628329
Trends Pharmacol Sci. 2009 Jun;30(6):303-12
pubmed: 19443052
J Invest Dermatol. 2014 Oct;134(10):2620-2629
pubmed: 24662765
Genes Dev. 2014 Feb 15;28(4):328-41
pubmed: 24532713
PLoS One. 2012;7(12):e52898
pubmed: 23300809
Dermatol Surg. 2019 Feb;45(2):313-316
pubmed: 29957662
Am J Pathol. 2007 Jun;170(6):2089-99
pubmed: 17525275
Cancer Res. 1983 Dec;43(12 Pt 1):5995-6011
pubmed: 6196111
J Cell Biochem. 1982;19(3):249-57
pubmed: 6296169
J Skin Cancer. 2012;2012:147863
pubmed: 23316365
Cell Cycle. 2006 Aug;5(16):1840-6
pubmed: 16861904
Head Neck. 2013 Jan;35(1):86-93
pubmed: 22495823
Biochim Biophys Acta. 2007 Aug;1773(8):1213-26
pubmed: 17112607
Carcinogenesis. 2009 Jun;30(6):918-26
pubmed: 19321799
Cell Stem Cell. 2015 Apr 2;16(4):400-12
pubmed: 25842978
Front Oncol. 2018 Sep 25;8:396
pubmed: 30319965
PLoS One. 2013 Jun 10;8(6):e65403
pubmed: 23762360