PRC1 promotes GLI1-dependent osteopontin expression in association with the Wnt/β-catenin signaling pathway and aggravates liver fibrosis.
GLI
HSC
Liver fibrosis
Osteopontin
PRC1
Wnt/β-catenin
Journal
Cell & bioscience
ISSN: 2045-3701
Titre abrégé: Cell Biosci
Pays: England
ID NLM: 101561195
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
08
2019
accepted:
09
12
2019
entrez:
24
12
2019
pubmed:
24
12
2019
medline:
24
12
2019
Statut:
epublish
Résumé
PRC1 (Protein regulator of cytokinesis 1) regulates microtubules organization and functions as a novel regulator in Wnt/β-catenin signaling pathway. Wnt/β-catenin is involved in development of liver fibrosis (LF). We aim to investigate effect and mechanism of PRC1 on liver fibrosis. Carbon tetrachloride (CCl PRC1 was up-regulated in CCl PRC1 aggravated LF through regulating Wnt/β-catenin mediated GLI1-dependent osteopontin expression, providing a new potential therapeutic target for LF treatment.
Sections du résumé
BACKGROUND
BACKGROUND
PRC1 (Protein regulator of cytokinesis 1) regulates microtubules organization and functions as a novel regulator in Wnt/β-catenin signaling pathway. Wnt/β-catenin is involved in development of liver fibrosis (LF). We aim to investigate effect and mechanism of PRC1 on liver fibrosis.
METHODS
METHODS
Carbon tetrachloride (CCl
RESULTS
RESULTS
PRC1 was up-regulated in CCl
CONCLUSIONS
CONCLUSIONS
PRC1 aggravated LF through regulating Wnt/β-catenin mediated GLI1-dependent osteopontin expression, providing a new potential therapeutic target for LF treatment.
Identifiants
pubmed: 31867100
doi: 10.1186/s13578-019-0363-2
pii: 363
pmc: PMC6916466
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests, and all authors should confirm its accuracy.
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