Antibacterial Activity of Chlorhexidine-Killed Bacteria: The Zombie Cell Effect.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
17 Dec 2019
17 Dec 2019
Historique:
received:
01
02
2019
accepted:
15
10
2019
entrez:
24
12
2019
pubmed:
24
12
2019
medline:
24
12
2019
Statut:
epublish
Résumé
We report a biocidal zombie effect of chlorhexidine, a wide-scope biocidal agent commonly used in disinfectant and antiseptic formulations. The zombie effect refers to the ability of dead bacteria killed by a biocidal agent to act as efficient biocidal agents toward a new generation of viable bacteria. The killed bacteria serve as a reservoir for the antibacterial agent incorporated within them; and the new viable population of bacteria acts as a trap of the bioactive agent, shifting the equilibrium of this agent between the reservoir in the dead cells and their aqueous environment. This report is a major generalization of the zombie phenomenon reported previously for silver from the points of view of extending to organic antibacterial agents; extending the effect to both Gram-negative-
Identifiants
pubmed: 31867476
doi: 10.1021/acsomega.9b00297
pmc: PMC6921249
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20868-20872Informations de copyright
Copyright © 2019 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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