A prospective evaluation of health-related quality of life after skull base re-irradiation.
health-related quality of life
intensity modulation
patient-reported outcomes
quality of life
re-irradiation
skull base tumor
stereotactic body radiotherapy
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
04
03
2019
revised:
05
11
2019
accepted:
13
11
2019
pubmed:
24
12
2019
medline:
22
6
2021
entrez:
24
12
2019
Statut:
ppublish
Résumé
To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT). Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires. Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous. Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.
Identifiants
pubmed: 31868271
doi: 10.1002/hed.26037
pmc: PMC9673230
mid: NIHMS1850223
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-497Subventions
Organisme : NCI NIH HHS
ID : R01 CA214825
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA225190
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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