Sensory signals mediating high blood pressure via sympathetic activation: role of adipose afferent reflex.
adipose tissue
heart
kidney
sensory neurons
sympathetic activation
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
pubmed:
24
12
2019
medline:
12
5
2020
entrez:
24
12
2019
Statut:
ppublish
Résumé
Blood pressure regulation in health and disease involves a balance between afferent and efferent signals from multiple organs and tissues. Although there are numerous reviews focused on the role of sympathetic nerves in different models of hypertension, few have revised the contribution of afferent nerves innervating adipose tissue and their role in the development of obesity-induced hypertension. Both clinical and basic research support the beneficial effects of bilateral renal denervation in lowering blood pressure. However, recent studies revealed that afferent signals from adipose tissue, in an adipose-brain-peripheral pathway, could contribute to the increased sympathetic activation and blood pressure during obesity. This review focuses on the role of adipose tissue afferent reflexes and briefly describes a number of other afferent reflexes modulating blood pressure. A comprehensive understanding of how multiple afferent reflexes contribute to the pathophysiology of essential and/or obesity-induced hypertension may provide significant insights into improving antihypertensive therapeutic approaches.
Identifiants
pubmed: 31868518
doi: 10.1152/ajpregu.00079.2019
pmc: PMC7052594
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
R379-R389Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL135158
Pays : United States
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