The randomized trials of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans.
Acanthosis nigricans
topical retinoid
tretinoin
urea
Journal
The Journal of dermatological treatment
ISSN: 1471-1753
Titre abrégé: J Dermatolog Treat
Pays: England
ID NLM: 8918133
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
pubmed:
24
12
2019
medline:
26
11
2021
entrez:
24
12
2019
Statut:
ppublish
Résumé
Acanthosis nigricans is characterized as hyperpigmented skin and velvety surface on posterior and lateral folds of the neck and the intertriginous areas. This study aimed to assess the efficacy of topical 10% urea cream compared to 0.025% tretinoin cream in the treatment of acanthosis nigricans. This was an 8-week trial, double-blind, randomized, comparative study of topical 10% urea and 0.025% tretinoin for the treatment of the neck hyperpigmentation. The Mexameter MX18 was used for assessing treatment efficacy. The global evaluation scale was also used to evaluate the overall success rate at weeks 2, 4, and 8 of the study. There was a statistically significant difference between 10% urea and 0.025% tretinoin in the treatment of acanthosis nigricans ( Both medications significantly improved neck hyperpigmentation. However, the efficacy of 0.025% tretinoin was significantly better than 10% urea in the treatment of acanthosis nigricans. TCTR20180703003.
Sections du résumé
BACKGROUND
BACKGROUND
Acanthosis nigricans is characterized as hyperpigmented skin and velvety surface on posterior and lateral folds of the neck and the intertriginous areas. This study aimed to assess the efficacy of topical 10% urea cream compared to 0.025% tretinoin cream in the treatment of acanthosis nigricans.
MATERIAL AND METHODS
METHODS
This was an 8-week trial, double-blind, randomized, comparative study of topical 10% urea and 0.025% tretinoin for the treatment of the neck hyperpigmentation. The Mexameter MX18 was used for assessing treatment efficacy. The global evaluation scale was also used to evaluate the overall success rate at weeks 2, 4, and 8 of the study.
RESULTS
RESULTS
There was a statistically significant difference between 10% urea and 0.025% tretinoin in the treatment of acanthosis nigricans (
CONCLUSION
CONCLUSIONS
Both medications significantly improved neck hyperpigmentation. However, the efficacy of 0.025% tretinoin was significantly better than 10% urea in the treatment of acanthosis nigricans.
CLINICAL TRIALS REGISTRY
BACKGROUND
TCTR20180703003.
Identifiants
pubmed: 31868565
doi: 10.1080/09546634.2019.1708855
doi:
Substances chimiques
Keratolytic Agents
0
Tretinoin
5688UTC01R
Urea
8W8T17847W
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM