Unilateral primary aldosteronism as an independent risk factor for vertebral fracture.
osteoporosis
unilateral primary aldosteronism
vertebral fracture
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
15
09
2019
revised:
13
12
2019
accepted:
19
12
2019
pubmed:
24
12
2019
medline:
27
3
2021
entrez:
24
12
2019
Statut:
ppublish
Résumé
Primary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF. To evaluate whether unilateral PA is associated with the prevalence of VF. This was a retrospective cross-sectional study in a single referral centre. We identified 210 hypertensive patients whose clinical data were available for case-detection results. One hundred and fifty-two patients were diagnosed with PA using captopril challenge tests. We measured the prevalence of VF, according to PA subtype. One hundred thirteen patients with PA were subtype classified by adrenal vein sampling. Of these, 37 patients had unilateral PA, 76 patients had bilateral PA, 58 patients had non-PA; 39 patients with PA were not subtype-classified. Patients with PA had a higher prevalence of VF (29%, 44/152) than those with non-PA (12%, 7/58; P = .011). Moreover, unilateral PA had a higher prevalence of VF (46%, 17/37) than bilateral PA (20%, 15/76; P = .021). There was no significant difference in the prevalence of VF between bilateral PA and non-PA. Unilateral PA was an independent risk factor for VF after adjusting for age and sex (OR: 3.16, 95% confidence interval: 1.12-8.92; P = .017). Among patients with unilateral PA, serum cortisol concentrations after 1-mg dexamethasone suppression test were higher in those with VF (1.32 ± 0.67 g/dL) than those without (0.96 ± 0.33 g/dL; P = .048). Unilateral PA is an independent risk factor for VF.
Substances chimiques
Aldosterone
4964P6T9RB
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-213Informations de copyright
© 2019 John Wiley & Sons Ltd.
Références
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