Arcuate Kisspeptin Neurons Coordinate Reproductive Activities with Metabolism.
Journal
Seminars in reproductive medicine
ISSN: 1526-4564
Titre abrégé: Semin Reprod Med
Pays: United States
ID NLM: 100909394
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
entrez:
24
12
2019
pubmed:
24
12
2019
medline:
26
6
2020
Statut:
ppublish
Résumé
Hypothalamic control of fertility is the quintessential homeostatic function. However, fertility is metabolically demanding; so, there must be coordination between energy states and reproductive functions. Because gonadotropin-releasing hormone (GnRH) neurons are devoid of many of the critical metabolic hormone receptors for sensing nutrient levels, it has long been recognized that the sensing of energy stores had to be done by neurons presynaptic to GnRH neurons. Some of the obvious players have been the anorexigenic proopiomelanocortin (POMC) and orexigenic neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons, both of which are in close apposition to the median eminence, a circumventricular organ. Indeed, POMC and NPY/AgRP neurons are inversely regulated by glucose and metabolic hormones including insulin and leptin. However, their synaptic connections with GnRH neurons are sparse and/or GnRH neurons are lacking the postsynaptic receptors to mediate the appropriate physiological response. Kisspeptin neurons were discovered in the early part of this century and subsequently shown to project to and control GnRH neuronal excitability. In fact, more recently the arcuate kisspeptin neurons have been identified as the command neurons driving pulsatile release of GnRH. Subsequently, it was shown that arcuate kisspeptin neurons express not only steroid hormone receptors but also metabolic hormone receptors such that similar to POMC neurons, they are excited by insulin and leptin. Therefore, based on the premise that arcuate kisspeptin neurons are the key neurons coordinating energy states with reproduction, we will review not only how these vital neurons control pulsatile GnRH release but how they control energy homeostasis through their synaptic connections with POMC and NPY/AgRP neurons and ultimately how E2 can regulate their excitability.
Identifiants
pubmed: 31869841
doi: 10.1055/s-0039-3400251
pmc: PMC7159845
mid: NIHMS1569705
doi:
Substances chimiques
Kisspeptins
0
Gonadotropin-Releasing Hormone
33515-09-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-140Subventions
Organisme : NINDS NIH HHS
ID : R01 NS043330
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS038809
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS038809
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK068098
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK068098
Pays : United States
Informations de copyright
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Déclaration de conflit d'intérêts
None declared.
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