Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta.
Aging
DTI
Iron deposition
Locus coeruleus
Substantia nigra
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
26
05
2019
revised:
19
11
2019
accepted:
22
11
2019
pubmed:
25
12
2019
medline:
15
9
2020
entrez:
25
12
2019
Statut:
ppublish
Résumé
Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here, we use high-resolution diffusion-weighted MRI to investigate microstructural and compositional changes in LC and SNpc in young and older adult cohorts, as well as their relationship with cognition. In LC, the older cohort exhibited a significant reduction in mean and radial diffusivity, but a significant increase in fractional anisotropy compared with the young cohort. We observed a significant correlation between the decrease in LC mean, axial, and radial diffusivities and measures examining cognition (Rey Auditory Verbal Learning Test delayed recall) in the older adult cohort. This observation suggests that LC is involved in retaining cognitive abilities. In addition, we observed that iron deposition in SNpc occurs early in life and continues during normal aging.
Identifiants
pubmed: 31870645
pii: S0197-4580(19)30424-5
doi: 10.1016/j.neurobiolaging.2019.11.016
pmc: PMC7064384
mid: NIHMS1545538
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-97Subventions
Organisme : NIA NIH HHS
ID : R00 AG047334
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG054804
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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