Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.

Animals Antibodies / isolation & purification Antibodies, Blocking / isolation & purification Avian Proteins / genetics Bursa of Fabricius / metabolism Cell Differentiation Cells, Cultured Chick Embryo Chickens / immunology Gene Expression Regulation, Developmental Immunoglobulin Fc Fragments / genetics Macrophage Colony-Stimulating Factor / genetics Macrophages / physiology Receptor, Macrophage Colony-Stimulating Factor / genetics Recombinant Fusion Proteins / genetics
CSF1 Chicken Macrophages Neutralising antibody

Journal

Developmental and comparative immunology
ISSN: 1879-0089
Titre abrégé: Dev Comp Immunol
Pays: United States
ID NLM: 7708205

Informations de publication

Date de publication:
04 2020
Historique:
received: 25 10 2019
revised: 18 12 2019
accepted: 18 12 2019
pubmed: 25 12 2019
medline: 22 6 2021
entrez: 25 12 2019
Statut: ppublish

Résumé

Macrophage colony-stimulating factor (CSF1) is an essential growth factor to control the proliferation, differentiation and survival of cells of the macrophage lineage in vertebrates. We have previously produced a recombinant chicken CSF1-Fc fusion protein and administrated it to birds which produced a substantial expansion of tissue macrophage populations. To further study the biology of CSF1 in the chicken, here we generated anti-chicken CSF1 antibodies (ROS-AV181 and 183) using CSF1-Fc as an immunogen. The specific binding of each monoclonal antibody was confirmed by ELISA, Western blotting and immunohistochemistry on tissue sections. Using the anti-CSF1 antibodies, we show that chicken bone marrow derived macrophages (BMDM) express CSF1 on their surface, and that the level appears to be regulated further by exogenous CSF1. By capture ELISA circulating CSF1 levels increased transiently in both layer and broiler embryos around the day of hatch. The levels of CSF1 in broilers was higher than in layers during the first week after hatch. Antibody ROS-AV183 was able to block CSF1 biological activity in vitro and treatment of hatchlings using this neutralising antibody in vivo impacted on some tissue macrophage populations, but not blood monocytes. After anti-CSF1 treatment, CSF1R-transgene reporter expressing cells were reduced in the bursa of Fabricius and cecal tonsil and TIM4

Identifiants

DOI: 10.1016/j.dci.2019.103586 PMID: 31870792 PMC: PMC6996135
pubmed: 31870792
pii: S0145-305X(19)30501-4
doi: 10.1016/j.dci.2019.103586
pmc: PMC6996135
pii:
doi:

Substances chimiques

Antibodies 0
Antibodies, Blocking 0
Avian Proteins 0
Immunoglobulin Fc Fragments 0
Recombinant Fusion Proteins 0
Macrophage Colony-Stimulating Factor 81627-83-0
Receptor, Macrophage Colony-Stimulating Factor EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103586

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011925/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/10002071
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 099164/Z/12/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/20320000
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Zhiguang Wu (Z)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Rakhi Harne (R)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Cosmin Chintoan-Uta (C)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Tuan-Jun Hu (TJ)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Robert Wallace (R)

The Department of Orthopedic Surgery, University of Edinburgh, Chancellor's Building, Edinburgh BioQuarter, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

Amanda MacCallum (A)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Mark P Stevens (MP)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Pete Kaiser (P)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Adam Balic (A)

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK. Electronic address: adam.balic@roslin.ed.ac.uk.

David A Hume (DA)

Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, 4104, Australia. Electronic address: David.Hume@uq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Regulation and function of macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Regulation and function of macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps bloquants › Regulation and function of macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines aviaires › Regulation and function of macrophage...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Bourse de Fabricius › Regulation and function of macrophage...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Regulation and function of macrophage...
questionsmedicales.fr › Cellules › Cellules cultivées › Regulation and function of macrophage...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Embryon de poulet › Regulation and function of macrophage...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Poulets › Regulation and function of macrophage...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Regulation and function of macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Fragments d'immunoglobuline › Fragments Fc des immunoglobulines › Regulation and function of macrophage...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de croissance hématopoïétique › Facteurs de stimulation des colonies › Facteur de stimulation des colonies de macrophages › Regulation and function of macrophage...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Regulation and function of macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Récepteur du facteur de stimulation des colonies de macrophages › Regulation and function of macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Protéines de fusion recombinantes › Regulation and function of macrophage...