Interfacial bonding in formulated bilayer tablets.

Cellulose / chemistry Chemistry, Pharmaceutical / methods Drug Compounding / methods Drug Delivery Systems Excipients / chemistry Hypromellose Derivatives / chemistry Lactose / chemistry Pressure Tablets Technology, Pharmaceutical / methods
Bilayer tablet Failure mode HPMC Interfacial bonding strength Lactose Microcrystalline cellulose

Journal

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 30 04 2019
revised: 20 10 2019
accepted: 15 12 2019
pubmed: 25 12 2019
medline: 3 10 2020
entrez: 25 12 2019
Statut: ppublish

Résumé

To take full advantage of the drug delivery benefits offered by bilayer tablets, the common issue of weak interfacial bonding strength (IBS) with manufacturing must be overcome. This work seeks to characterize the effects of composition in individual layers and compaction pressure on the IBS. Mixtures of MCC and lactose in different ratios with and without HPMC were used where the first layer was compacted with two different pressures (20 and 100 MPa) followed by a second layer compaction pressure of 200 MPa. After identifying the failure mode as either at the interface or within a layer, the complex trends of bilayer tablet IBS as a function of MCC content were explained by considering the interplay between particle bonding strength and bonding area at the interface.

Identifiants

DOI: 10.1016/j.ejpb.2019.12.009 PMID: 31870828
pubmed: 31870828
pii: S0939-6411(19)31320-7
doi: 10.1016/j.ejpb.2019.12.009
pii:
doi:

Substances chimiques

Excipients 0
Tablets 0
Hypromellose Derivatives 3NXW29V3WO
Cellulose 9004-34-6
Lactose J2B2A4N98G
microcrystalline cellulose OP1R32D61U

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

69-75

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Shao-Yu Chang (SY)

Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.

Changquan Calvin Sun (CC)

Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA. Electronic address: sunx0053@umn.edu.

Articles similaires

Mathematical modeling of vancomycin release from Poly-L-Lactic Acid-Coated implants.

Papon Thamvasupong, Kwanchanok Viravaidya-Pasuwat
1.00
Vancomycin Polyesters Anti-Bacterial Agents Models, Theoretical Drug Liberation

Correlation between subretinal tissue plasminogen activator and air injection rates with pressure in a retina mimicking model.

Na Hee Kim, Minsub Lee, Hyewon Chung et al.
1.00
Tissue Plasminogen Activator Retina Air Pressure Humans

Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers.

Prashant Kesharwani, Kratika Halwai, Saurav Kumar Jha et al.
1.00
Chitosan Humans Folic Acid Nanoparticles Drug Carriers

Bioefficiency of microencapsulated hemp leaf phytonutrient-based extracts to enhance in vitro rumen fermentation and mitigate methane production.

Srisan Phupaboon, Maharach Matra, Ronnachai Prommachart et al.
1.00
Animals Rumen Methane Fermentation Cannabis

Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Cellulose › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie pharmaceutique › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Excipients › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Cellulose › Dérivés de l'hypromellose › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Glucides › Sucres › Diholoside › Lactose › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Pression › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Préparations pharmaceutiques › Comprimés › Interfacial bonding in formulated bilayer tablets.
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Interfacial bonding in formulated bilayer tablets.